A Rare Case of Hepatocellular Carcinoma with Metastasis to The Thyroid
Journal Title: Journal of Clinical Medical Research - Year 2024, Vol 5, Issue 2
Abstract
Background: Liver cancer is among the top five causes of cancer death globally. Hepatocellular Carcinoma (HCC) accounts for up to 90% of primary liver neoplasms in adults. The incidence of thyroid me-tastasis from HCC is rare and estimated from 0.8 to 12%. This report describes a 51-year-old man presenting with hypercalcemia and known metastatic HCC with new metastasis to the thyroid gland. Case Report: A 51-year-old male was admitted due to symptomatic hypercalcemia. His medical history included HCC with metastasis to the retroperitoneal lymph nodes diagnosed one year prior. Computed tomography revealed an enlarging liver mass, diffuse lymphadenopathy and many osseous lytic lesions. Ultrasound of the neck revealed abnormal right cervical lymph nodes and a heterogeneous mass replacing the right thyroid gland. Biopsy of the right cervical lymph node immunohistochemical stained positive for PAN-K, Glypican-3, HepPar1 and Anti-Arginase and negative for p40 and CEA-poly, supporting the diagnosis for metastatic HCC. His hospital course was complicated by dysphagia, spontaneous bacterial peritonitis and acute-on-chronic liver failure. Despite aggressive resuscitation, he continued to decline and ultimately pursued hospice care. Conclusion: This case illustrates the need to have a high index of suspicion for thyroid metastasis in HCC patients presenting with a new-onset cervical mass, dysphagia or hypercalcemia. Metastatic cancer to the thyroid gland is generally considered a poor prognostic factor, as seen in this case with the rapid decline. This case demonstrates an extremely rare presentation of HCC with metastasis to the thyroid gland.
Authors and Affiliations
Shelby Ploucher, Odelvys Granela, Rachel D Truong, Van Anh T, Brian Shaw, Jacqueline N Kropf, Steve J Carlan*
Keywords
Related Articles
- EP ID EP743191
- DOI https://doi.org/10.46889/JCMR.2024.5209
- Views 11
- Downloads 0
Presternal Scrofuloderma in a HIV Infected Patient Case Report and Discussion of the Literature Data
Scrofuloderma is a cutaneous extension of Mycobacterium tuberculosis (and rarely Mycobacterium bovis or Calmette-Guerin bacillus) from a local focus. It is a rare form of extra-pulmonary tuberculosis, starting as a painl...
Alteration of Endocrine Functions and Reproductive Outcome Following Consumption of Edible Crops Grown Around E-Waste Dumpsite Using Albino Wistar Rat Model
Electronic waste (e-waste) is the term used to describe old, end-of-life or discarded appliances using electricity in one form or the other which are destined for reuse, resale, salvage, recycling but most importantly di...
Trunnionosis: What We Should Know As an Orthopaedic Surgeon
The main question is what is Trunnionosis and what do we need to know as a surgeon. So trunnionosis is basically metallosis. It is the generation of metallic debris from a combination of motion at head on neck junction...
Predictors of COVID-19 Related Fatalities during the First Three Months of the Pandemic: An Ecological Study of 114 Countries
Background: Coronavirus disease 2019 (COVID-19) has costed the lives of more than 2 million people during the first wave of the pandemic with the number of fatalities varying among different countries. Thus, we aimed to...
Real Time Health Monitoring For Palliative Patients through MSE-WBAN Architecture
The mobile-Health (mHEALTH) is the application of digital technology in health care services to bring the health care services into a digital format and to introduce the culture of digitalization in health-related matt...