A rare case of Penicillium Marneffei infection in an HIV infected individual with Immune Reconstitution Inflammatory Syndrome (IRIS) along with possible penicillium meningitis in the Northeast Indian state of Manipur: A case report
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2018, Vol 17, Issue 8
Abstract
Penicillium marneffei is a dimorphic fungus that is endemic to Southeast Asia & the Northeast Indian state of Manipur. Manipur is one of the six high HIV prevalence states in India. We report a rare case of newly diagnosed HIV patient who was started on antiretroviral therapy & later on developed Immune Reconstitution Inflammatory Syndrome (IRIS) with penicilliosis as well. Patient also developed meningitis during his hospital stay & investigations for the same turned out to be negative for commonly tested opportunistic infections. The possibility of penicillium meningitis was taken into account. The clinical presentation & preliminary cerebrospinal fluid findings resembled those of penicillium meningitis cases studied elsewhere. Further definitive investigations could not be undertaken as the patient’s condition deteriorated & the patient eventually expired. This case report aims at stressing the need to take into account the possibility of penicillium infections of the nervous system, which are not seen commonly.
Authors and Affiliations
Ugen Gyatso N. Bhutia, Kshetrimayum Silpa, Banteilang Challam, Dhanaraj Singh Chongtham
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