A rare case of primary clear cell sarcoma of the leg in an elderly
Journal Title: MedPulse -International Medical Journal - Year 2014, Vol 1, Issue 3
Abstract
Clear cell sarcoma (CCS) is an aggressive, rare soft-tissue tumor representing approximately 1 per cent of all soft tissue sarcomas. Also called malignant melanoma of soft parts because it shares a melanocytic phenotype that include presence of melanin, ultra structural evidence of melanosomes, and immunohisto chemical staining for S-100 protein and melanoma associated antigen HMB-45. Diagnostic difficulties arise with metastatic malignant melanoma to soft tissue. DNA ploidy analysis reveals that CCS has a diploid or lesser degree of an euploidy when compared with malignant melanoma. This paper reports on a clear cell sarcoma occurring at a very old age in upper part of leg. The tumor consisted of round to spindle cells with clear cytoplasm and multinucleated giant cells. Both S100 and HMB45 were positive. DNA analysis by Flow Cytometry showed a diploid pattern of growth. Patient underwent wide excision of the tumor. The case supports the contention that distinctive histology, IHC and DNA ploidy analysis were helpful to delineate CCS. Wide excision with negative margins remains the mainstay of treatment.
Authors and Affiliations
Monoj Kumar Deka, Anuradha Talukdar, Ritesh Tapkire, Rajeev Kumar, Akalesh K Verma, Ravi Kannan
Keywords
Related Articles
- EP ID EP179558
- DOI -
- Views 101
- Downloads 0
Clinical profile of orofacial malignancies at tertiary care hospital in Aurangabad district of Maharashtra: an observational study
Background: Oral and maxillofacial pathologies are diverse and reports from different parts of the world show differences in the pattern of maxillofacial tumours seen. There is a need to observe and analyze the clinical...
Enteric fever in and around Ambajogai, Maharashtra
Enteric fever is an acute communicable disease caused by Salmonella species and it occurs in all parts of the world. Enteric fever is a major public health problem in India. Definitive diagnosis of typhoid can be made by...
Effect of low dose aspirin therapy during period of placentation on maternal and neonatal outcome
Background: Pre-eclampsia is a multisystem disorder usually associated with raised blood pressure and proteinuria. A relatively common complication of the second half of pregnancy, it affects 2-8% of pregnancies. The rol...
Assess the knowledge on peri operative nursing care among nursing students at selected college
Background: Surgery is a technology consisting of a physical intervention on tissues, and muscle. Surgical procedures are commonly categorized by urgency, type of procedure, body system involved, degree of invasiveness,...
Prevalence of neuropsychiatric disorders and quality of life in post stroke patients in southern India
Background: Stroke is the third commonest cause of death worldwide after coronary heart disease and cancer of all types. Efficacious treatment until recently has centered around management of risk factors and co-morbid c...