A Rare Case of Thecoma In a Dog

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A Rare Case of Thecoma In a Dog

Journal Title: Biomedical Journal of Scientific & Technical Research (BJSTR) - Year 2019, Vol 19, Issue 2

Abstract

Thecoma is an ovarian tumour which has rarely been described in dog and must be differentiated from other similar neoplasm such as granulosa cell tumour, clear cell carcinoma, luteoma, fibroma, above all by histopathological examination. Aim of the paper is to report the histochemical and immunohistochemical findings useful to identify this tumour rarely found in dog. Tumour tissue was negative for cytokeratin and HBME-1, whereas strong immunopositivity with vimentin, calretinin and inhibin was seen; Gomori histochemical stain highlighted an abundant reticulin network among neoplastic cells. Negativity to cytokeratin and HBME-1 excluded the differential diagnosis of fibroma, while positivity to vimentin, calretinin and inhibin supported the differential diagnosis of granulosa cell tumour. The absence of spindle cells and strong presence of reticulin among tumour cells confirmed the final diagnosis of thecoma.Ovarian tumours represent a rare neoplastic condition in dogs and is generally observed in older subjects; they are classified based on the tissue involved; epithelial, stromal and germinal [1]. Among them, sex cord-stromal tumours are generally represented by granulosa cell tumours and rarely thecomas or interstitial cell tumours [2]. Granulosa cell tumours are generally hormone-active neoplasms showing variable macroscopic features, often very large, smooth and grey-yellowish in colour. On a cut surface, differently sized cysts with variable wall thickness and haemorrhages may be observed. Histologically, granulosa cell tumours are made up of clusters of granulosa mature cells, separated by connective septa. Thecomas are characterized by large masses with a lardaceous aspect and fibrous consistence, deriving from the follicular theca, mainly the internal one. Thecomas have a very low incidence and are usually benign with an expansive growth. Macroscopically, they are characterized by a white-yellowish or orange voluminous fibrous mass, with the presence of necrotic or haemorrhagic foci. Histologically, thecomas are characterized by pale, densely packed, cells with a variable amount of fibrocytes and fibroblasts, among which some sparse follicles may be seen [2]. Tumours consist of oval or spindle-shaped cells, irregularly arranged in clumps separated by fibrous septa or interlacing bundles, which are not encapsulated. Individual cells have round or elongated nuclei, and the cytoplasm may contain lipid vacuoles, which are indicative of steroid hormone production [3,4]. Thecomas in bitches are rarely reported and the distinction between thecoma and other mesenchymal tumours such as leiomyoma and fibroma can be difficult [5]. To distinguish this tumour from its related forms, it is necessary to use histochemical and immunohistochemical techniques [6-9]. The aim of the present paper is to show a rare case of thecoma in dog describing the histochemical and immunohistochemical patterns useful for its diagnosis.

Authors and Affiliations

C Iaria, JM Abbate, S Mazzullo, A Ieni, A La pietra, G Mazzullo

Keywords

Diagnosis; Dog; Immunohistochemistry; Tumour Journals on Biomedical Engineering Journals on Biomedical Science Journal on medical genetics Journals on Cancer medicine Journals on Medical Informatics Journals on Biomedical Imaging Journals on Biomedical Intervention Journals on Medical Microbiology Journals on Medical Casereports Journals on Medical drug and theraputics

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EP ID EP620681
DOI 10.26717/BJSTR.2019.19.003270
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