A RARE CASE OF YELLOW PHOSPHOROUS POISONING WITH ACUTE CHOLESTATIC HEPATITIS, BICYTOPENIA AND IMPENDING HEPATIC FAILURE
Journal Title: International Journal of Pharmacy and Pharmaceutical Sciences - Year 2016, Vol 8, Issue 4
Abstract
Yellow phosphorus is a protoplasmic poison (a potent hepatotoxin). Fulminant poisoning results from ingestion of more than 1 to 2 g. An 18 y old adult male presented with ingestion of rodenticide poison containing 3 percent phosphorous in paste form. He was asymptomatic during the first day of hospitalization. He developed jaundice on the second day. On evaluation, his total leukocyte count was 1.800 (109/l) on the day of admission, which improved to 4.400 (109/l) on the 7th day. His platelet count was 1.53 (109/l) on the day of admission, which decreased daily till 0.80 (109/l) on the 7th day of hospitalization. His prothrombin time started deranging from the second day of admission with a crest of 38 s and INR 2.98 noted on the 5th day. He was given N-acetyl cysteine on the 5th day following which PT/INR began to improve and reached to a baseline normal. The regimen of N-acetyl cysteine used was a loading dose of 150 mg/kg IV over 1 h, followed by 50 mg/kg IV over 4 h and 100 mg/kg IV over 16 h. He was also treated with fresh frozen plasma and intravenous vitamin k. The man made a dramatic recovery and became stable.Keywords: India, Kerala, Kottakkal, Phosphorous, Poisoning, N-acetyl cysteine, Hepatitis, Hepatic failure
Authors and Affiliations
Shiju K. Sleeba, Midhun Raj, Pa Kabeer, Dipu K. P.
Keywords
Related Articles
- EP ID EP577757
- DOI -
- Views 65
- Downloads 0
DEVELOPMENT AND VALIDATION OF STABILITY INDICATING RP-HPLC METHOD FOR ESTIMATION OF BALOFLOXACIN IN BULK AND TABLET DOSAGE FORM
Objective: The objective of the method was to develop a simple, rapid, efficient, cost effective and reproducible, stability indicating (RP-HPLC) Reverse Phase High Performance Liquid Chromatography method for the estima...
PROTECTIVE EFFECT OF COMMIPHORA MUKUL GUM RESIN ON BRAIN IN STREPTOZOTOCIN-INDUCED DIABETIC RATS
Objective: The present study was undertaken to investigate the hypolipidemic activity of ethanolic extract of Commiphora mukul gum resin (EtCMGR) on the brain of streptozotocin (STZ) induced diabetic Wistar rats.Methods:...
PHYSICOCHEMICAL, PHYTOCHEMICALS AND ANTIOXIDANT EVALUATION OF GUAZUMA ULMIFOLIA FRUIT
Objective: The present study was designed to evaluate the physicochemical, qualitative, quantitative analysis and antioxidant activity of ethanol fruit extract of Guazuma ulmifolia. Studies were carried out to detect the...
TOTAL POLYPHENOLIC CONTENT AND ANTIOXIDANT ACTIVITY OF SILYBUM MARIANUM CULTURES GROWN ON DIFFERENT GROWTH REGULATORS
Objective: The present study was designed to study the effect of supplementing Silybum marianum cultures with different combinations and concentrations of growth regulators on the total phenolic content and the antioxida...
INFLUENCE OF BINDING SOLUTION CONCENTRATION, DRYING DURATION AND DRYING TEMPERATURE ON PHYSIOCHEMICAL PERFORMANCE OF NORFLOXACIN GRANULES AND TABLETS
Objective: To investigate the possible individual and joined influences that binding solution concentration, drying temperature and drying duration might have on the physiochemical attributes of granules and tablets usin...