A RECENT APPROACH FOR SOLUBILITY AND BIOAVAILABILITY ENHANCEMENT: SOLID DISPERSION
Journal Title: Journal of Drug Discovery and Therapeutics - Year 2013, Vol 1, Issue 4
Abstract
Currently only about 8% of the new molecules have both high solubility and permeability. The drugs therapeutic efficacy depends upon the bioavailability and ultimately upon the solubility. Improving oral bioavailability of drugs those given as solid dosage forms remains a challenge due to solubility problems. Various techniques are used for the enhancement of the solubility of poorly soluble drugs which include nanonization, sonocrystallization, micronization, supercritical fluid method, spray freezing into liquid and lyophilization, evaporative precipitation into aqueous solution, use of surfactant, use of salt forms, solvent deposition, use of co-solvent, hydrotropy method, solubilizing agents, modification of the crystal habit, co-crystallisation, complexation and drug dispersion in carriers. Among several methods, solid dispersion has attracted attention of the researchers for previous 50 years. The term solid dispersion refers to a group of solid products consisting of at least two different components, generally a hydrophilic inert carrier or matrix and a hydrophobic drug.
Authors and Affiliations
Patel Chirag J*| Editor-in-Chief, Tyagi Pharmacy Association (TPA) & Scientific Writer (Pharmacy), Chattarpur, New Delhi, India-110074., Prof. Satyanand Tyagi| President & Founder, Tyagi Pharmacy Association (TPA) & Scientific Writer (Pharmacy), Chattarpur, New Delhi, India-110074, Dadarwal Poonam| Department of Pharmaceutics, Maharishi Arvind Institute of Pharmacy, Mansarovar, Jaipur, Rajasthan, India-302020., Mangukia Dhruv| Department of Pharmaceutics, Maharishi Arvind Institute of Pharmacy, Mansarovar, Jaipur, Rajasthan, India-302020., Pravin Yadav| Department of Pharmaceutics, Maharishi Arvind Institute of Pharmacy, Mansarovar, Jaipur, Rajasthan, India-302020., Sojitra Ishita| Department of Pharmaceutics, Parul Institute of Pharmacy, Vadodara, Gujarat, India-391760., M. Srujan Kumar| Department of Pharmaceutics, Samskruti College of Pharmacy, Ghatekesar, Hyderabad, Andhra Pradesh, India-501301., Anil K. Gupta| Research Scholar, Bhagwant University, Institute of Pharmacy & Research Center, Ajmer, Rajasthan, India-305004.
Keywords
Related Articles
- EP ID EP1376
- DOI -
- Views 504
- Downloads 31
An open label observational study for Drug adherence in Type 2 Diabetes Mellitus patients
Diabetes mellitus is a heterogeneous group of disorders characterized by abnormalities in carbohydrate, protein, and lipid metabolism. The central disturbance in diabetes mellitus is an abnormality in insulin production...
TREATMENT AND MANAGEMENT OF DIABETES WITH STEM CELL THERAPY: A NEWER SCIENTIFIC APPRAOCH
Diabetes is usually a lifelong (chronic) disease in which there are high levels of sugar in the blood. Diabetes, often referred to by doctors as diabetes mellitus, describes a group of metabolic diseases in which the per...
Comparative HPTLC analysis and invitro antioxidant study of Cinnamomum zeylanicum.
Cinnamon (Cinnamomum zeylanicum, Family: Lauraceae) is one of the world's oldest spices. The cinnamon, also known by Cassia, Sweet Wood, and Gui Zhi, is traditionally harvested in Asian countries. It is, perhaps, one of...
Formulation Development and evaluation of ibuprofen sustained release matrix tablet using Lepidium Sativum mucilage
Ibuprofen is one of the safest and most potent non-steroidal anti-inflammatory drugs (NSAID) available in the market. The objective of present study was to prepare and evaluate sustained release matrix tablets of ibuprof...
NEW SPECTROPHOTOMETRIC DETERMINATION OF LAMOTRIGINE IN BULK AND PHARMACEUTICAL DOSAGE FORM
The new, selective and sensitive visible spectrophotometric method have been developed for the estimation of Lamotrigine in bulk and in pharmaceutical preparations. The amino group in lamotrigine is diazotized with sodiu...