A RECENT APPROACH FOR SOLUBILITY AND BIOAVAILABILITY ENHANCEMENT: SOLID DISPERSION
Journal Title: Journal of Drug Discovery and Therapeutics - Year 2013, Vol 1, Issue 4
Abstract
Currently only about 8% of the new molecules have both high solubility and permeability. The drugs therapeutic efficacy depends upon the bioavailability and ultimately upon the solubility. Improving oral bioavailability of drugs those given as solid dosage forms remains a challenge due to solubility problems. Various techniques are used for the enhancement of the solubility of poorly soluble drugs which include nanonization, sonocrystallization, micronization, supercritical fluid method, spray freezing into liquid and lyophilization, evaporative precipitation into aqueous solution, use of surfactant, use of salt forms, solvent deposition, use of co-solvent, hydrotropy method, solubilizing agents, modification of the crystal habit, co-crystallisation, complexation and drug dispersion in carriers. Among several methods, solid dispersion has attracted attention of the researchers for previous 50 years. The term solid dispersion refers to a group of solid products consisting of at least two different components, generally a hydrophilic inert carrier or matrix and a hydrophobic drug.
Authors and Affiliations
Patel Chirag J*| Editor-in-Chief, Tyagi Pharmacy Association (TPA) & Scientific Writer (Pharmacy), Chattarpur, New Delhi, India-110074., Prof. Satyanand Tyagi| President & Founder, Tyagi Pharmacy Association (TPA) & Scientific Writer (Pharmacy), Chattarpur, New Delhi, India-110074, Dadarwal Poonam| Department of Pharmaceutics, Maharishi Arvind Institute of Pharmacy, Mansarovar, Jaipur, Rajasthan, India-302020., Mangukia Dhruv| Department of Pharmaceutics, Maharishi Arvind Institute of Pharmacy, Mansarovar, Jaipur, Rajasthan, India-302020., Pravin Yadav| Department of Pharmaceutics, Maharishi Arvind Institute of Pharmacy, Mansarovar, Jaipur, Rajasthan, India-302020., Sojitra Ishita| Department of Pharmaceutics, Parul Institute of Pharmacy, Vadodara, Gujarat, India-391760., M. Srujan Kumar| Department of Pharmaceutics, Samskruti College of Pharmacy, Ghatekesar, Hyderabad, Andhra Pradesh, India-501301., Anil K. Gupta| Research Scholar, Bhagwant University, Institute of Pharmacy & Research Center, Ajmer, Rajasthan, India-305004.
Keywords
Related Articles
- EP ID EP1376
- DOI -
- Views 457
- Downloads 31
Therapeutic impact of garden cress seeds incorporated ladoo among the selected anaemic adolescent girls (12-15 years)
Adolescents are the important segments of the global population. Their well being and the active participation are the fundamental needs for the development of the society. Nutritional problems of adolescent girls are co...
ANTIOXIDANT ACTIVITY OF HERBAL PLANTS: A RECENT REVIEW
Antioxidants or inhibitors of oxidation are compounds which retard or prevent the oxidation and in general prolong the life of the oxidizable matter. Majority of the diseases/disorders are mainly linked to oxidative stre...
PRESENT STATUS OF PHARMACY EDUCATION AND FUTURE PROSPECTS AND CHALLENGE OF PHARMACY PRACTICE IN BANGLADESH
Pharmacy is a multi-disciplinary subject composed of all aspects of drugs including its manufacturing, synthesis, quality control and quality assurance, marketing, handling, safety matters, patients care, invention, and...
A RECENT TRENDS IN ENHANCEMENT OF SOLUBILITY AND DISSOLUTION RATE OF POORLY SOLUBLE HYDROPHOBIC DRUGS BY USING PHYSICAL AND CHEMICAL MODIFICATIONS
The aim of this review was to improve the solubility and bioavailability of poorly soluble drugs by using various approaches like physical, chemical and others modifications or techniques. The ability to increase aqueous...
IKBKE GENE-A NEWLY POTENTIAL THERAPEUTIC TARGET FOR TREATING NON-SMALL CELL LUNG CANCER
The IKBKE gene is part of a family of enzyme complexes involved in increasing cellular inflammation. IKBKE over expression has been associated with breast and prostate cancers. However, it had not been linked to environm...