Development of proniosomes gel as a drug carrier for transdermal delivery of acyclovir
Journal Title: Journal of Drug Discovery and Therapeutics - Year 2014, Vol 2, Issue 6
Abstract
Non-ionic surfactant vesicles of acyclovir, an antiviral, were prepared by coacervation phase separation method. The prepared systems were characterised for encapsulation efficiency, shape, size and in vitro drug release scanning electron microscopy (SEM). Proniosomal prepared by using different polymers span 40, span 60, span 20, tween 20, tween 80 and cholesterol and soya lecithin. Among all proniosomal transdermal gel formulation, The results showed that acyclovir in all the formulations was successfully entrapped and a substantial change in release rate and an alteration in the encapsulation efficiency of acyclovir from proniosomes were observed upon varying the type of surfactant and cholesterol content The encapsulation efficiency of proniosomes prepared with Span 60,cholesterol and lecithin gave maximum encapsulation efficiency (89.70%) as compared to other compositions. , the niosomal gel formulation could be a promising transdermal delivery system acyclovir with prolonged drug release profiles.
Authors and Affiliations
Rajesh Asija*| Maharishi Arvind Institute of Pharmacy, Mansarover, Jaipur, Rajasthan, India, Deepak Sharma| Maharishi Arvind Institute of Pharmacy, Mansarover, Jaipur, Rajasthan, India, Haresh Nirmal| Maharishi Arvind Institute of Pharmacy, Mansarover, Jaipur, Rajasthan, India
Keywords
Related Articles
- EP ID EP1485
- DOI -
- Views 428
- Downloads 25
DIMENSIONLESS REYNOLDS NUMBER AS A DIMENSION FOR FLUID MECHANICS IN RHEOLOGY
Reynolds number, in fluid mechanics, a criterion of whether fluid (liquid or gas) flow is absolutely steady (streamlined, or laminar) or on the average steady with small unsteady fluctuations (turbulent). Whenever the Re...
FORMULATION AND EVALUATION OF SUSTAINED RELEASE TABLETS OF LABETALOL HYDROCHLORIDE USING HYDROPHILIC POLYMERS
Labetalol hydrochloride is used in treatment of hypertension. It has a short half life and undergoes extensive first pass metabolism. In the present study, labetalol hydrochloride 100 mg controlled release matrices were...
Matrix tablet- simplest method of sustaining drug action
Matrix tablet were designed to achieve the sustained released of drug from dosage form. Sustained release of drug is required to prolong the duration of action of drug, thus reducing the dosing frequency. Matrix tablet w...
AN OVERVIEW ON MORINGA OLEIFERA: A POTENTIAL MEDICINAL HERB
Moringa Oleifera tree is known as miracle tree, as an almost every part of this tree possesses product useful for humans. It is a multipurpose tree, used in very commonly in the spice, cosmetic oil, and as a medicinal us...
FORMULATION AND EVALUATION OF RIFAMPICIN SOLID LIPID NANOPARTICLES
The solid lipid nanoparticles (SLNs) are sub-micron sized colloidal carriers composed of physiological lipid dispersed either in water or in an aqueous surfactant solution. SLNs as colloidal drug carrier combine the adv...