FORMULATION AND EVALUATION OF SUSTAINED RELEASE TABLETS OF LABETALOL HYDROCHLORIDE USING HYDROPHILIC POLYMERS
Journal Title: Journal of Drug Discovery and Therapeutics - Year 2013, Vol 1, Issue 6
Abstract
Labetalol hydrochloride is used in treatment of hypertension. It has a short half life and undergoes extensive first pass metabolism. In the present study, labetalol hydrochloride 100 mg controlled release matrices were prepared by direct compression and in vitro drug dissolution studies were performed to find out the drug release rate and patterns. Hydroxypropyl methylcellulose, Hydroxypropyl cellulose and Hydroxyethyl cellulose were used as rate controlling polymers. Hydroxypropylmethylcellulose was used as primary rate controlling polymer and effects of addition of Hydroxypropyl cellulose and Hydroxyethyl cellulose on in-vitro drug dissolution were studied. Tablets were formulated using total polymer content as 30, 35 and 40 percent with 20 percent standard polymer content of Hydroxypropyl methylcellulose in all batches and varying the concentration of Hydroxypropyl cellulose and Hydroxyethyl cellulose in the range of 10, 15 and 20 percent. In-vitro drug release was carried out using USP Type II at 50 rpm in 900 ml of acidic dissolution medium (pH 1.2) for 2 hours, followed by 900 ml alkaline dissolution medium (pH 7.4) up to 12 hours. Several kinetic models were applied to the dissolution profiles to determine the drug release kinetics.
Authors and Affiliations
Ashtamkar Joel*| Department of Pharmacy, Vinayaka Missions University, Tamilnadu-India, Chugh Naresh| Department of Pharmacy, Vinayaka Missions University, Tamilnadu-India
Keywords
Related Articles
- EP ID EP1401
- DOI -
- Views 423
- Downloads 27
CORRELATION BETWEEN CHEMINFORMATICS AND BIOINFORMATICS IN DRUG DISCOVERY: A FARSIGHT OF PHARMACY-THE MILLENNIUM OATH
All drugs are chemicals but all chemicals are not drugs….This statement always focuses towards the footsteps of a new drug discovery by information technology which is concerned with the drug designing which is followed...
INVESTIGATION OF IN VITRO ANTHELMINTIC ACTIVITY OF FICUS ELASTICA LEAVES
The World Health Organization estimates that a staggering two billion people harbor parasitic worm infections. The increasing of anthelmintic drug resistance and the high cost of anthelmintic drugs led to the development...
Wound healing activity of the ethanolic extract of Solanum spirale leaves indigenous to north east India
As a part of present work objective are to investigate indigenous plant used in wound healing in northeast India, we hereby reported our findings related to wound healing activities of plant Solanum spirale (Solanaceae)...
PREVALENCE OF ANEMIA AMONG TWO INDEPENDENT GROUPS OF ADOLESCENT GIRLS-PRE MENARCHE AND POST MENARCHE
Anemia is a serious health issue for women and young children. It is ignored in most developing countries even though it is one of the most prevalent public health problems and has serious consequences for national deve...
SYNTHESIS, CHARACTERIZATION AND ANTIMICROBIAL SCREENING OF NOVEL SERIES OF BIS-IMIDAZO[1,2-a]PYRIDINE DERIVATIVES
imidazo[1,2-a]pyridine. All the synthesized compounds have been characterized by using elemental analysis, FT-IR, 1H NMR, 13C NMR spectroscopy and further supported by mass spectroscopy. Purity of all the compounds has b...