A Research on Autoimmunity in the Cases with Epilepsy or Febrile Convulsion
Journal Title: Scholars Journal of Applied Medical Sciences - Year 2014, Vol 2, Issue 1
Abstract
We aimed to investigate the relationship between the autoimmunity and epileptic paroxysmal disorders. It was a prospective case-control study (Setting: Ambulatory or hospitalized care). A total of 32 patients and 16 healthy children were included in the study. Anti-glutamate- N-methyl-D-aspartate receptor, anti-glutamic acid decarboxylase and anti-ganglioside (GM1, GM2, GM3, GD1a, GD1b, GT1b, and GQ1b) antibodies’ levels were evaluated. Overall, anti-ganglioside antibodies were found positive in approximately one third of the patients (11/32, %34.4). The positivity rate was 43.8% (7/16) in the epilepsy group (p>0.05) and 25% (4/16) in the febrile convulsions (FC) group (p>0.05) while it was 18.8% (3/16) in the control group. In the study group, the mean age of the patients with the autoantibody positivity (36.6±37 months) was significantly lower than the mean age of the patients with the autoantibody negativity (67.9±47.4 months) (p<0.05). The mean age of the patients with the autoantibody positivity was also significantly lower (43.7±45.8 months vs. 112±36.5 months) in the epilepsy group (p<0.05). In addition, while the electroencephalographic (EEG) abnormality was found significant in all four FC patients with the anti-ganglioside GT1b positivity (p<0.05); it was not remarkable in the epilepsy group with the anti-ganglioside positivity (p>0.05). It is determined that the autoantibody positivity may be cautionary in terms of the risk of epilepsy development and the persistent EEG abnormality in the patients with the newly diagnosed epilepsy and/or FC; and autoantibodies may become negative with the increased age. Keywords: Epilepsy, febrile convulsion, anti-ganglioside antibodies, anti-glutamate receptor antibody, anti-glutamic acid decarboxylase antibody, children
Authors and Affiliations
Eray Basman, Nimet Kabakus, Mustafa Aydin, Esra Kocoglu, Seyda Ozsoy, Aysu Kiyan
Keywords
Related Articles
- EP ID EP374306
- DOI -
- Views 65
- Downloads 0
Serum sodium, potassium and Proteins Levels in Protein Energy Malnutrition disorder
Protein-energy malnutrition (PEM) is a major public health problem in the tropical and subtropical regions of the world. The aim of this study was to estimate the concentration of serum sodium, potassium, total proteins,...
Analysis of Distal Femur Fractures Treated with Locking Compression Plate
Distal femur fractures are one of complex fractures to treat because they are often communitted, unstable and osteoporotic. Various modalities of treatment are available now with varied results. Introduction of locking c...
Effect of Short Term Administration of Diazepam and Bromazepam on Lipid Profile of Albino Wistar Rats (Rattus rattus)
Abstract: Diazepam and bromazepam though are restricted drugs are commonly used especially in this part of the world; it is a known fact that some medications has negative effect on lipid profile. The aim of this study i...
Prevalence of Internet Addiction among Medical Students
Abstract: There has been exponential growth in the use of internet since last decade in the whole world. Internet use is known to foster addictive behavior and may become major public health problem.Most medical schools...
Knowledge and Practice of Nursing Students on Health Care Ethics
Abstract: The nursing students are responsible for gaining knowledge about health care ethics and all nursing institutions or colleges either in worldwide or in Malaysia made ethics, moral and laws are included in their...