A Retrospective Critical Analysis of Intracranial Atypical Meningiomas Managed At a Tertiary Care Centre with a Rural Set up in Rural Area of India
Journal Title: International Journal of Medical Research Professionals - Year 2018, Vol 4, Issue 2
Abstract
Background: Atypical meningiomas are World Health Organization - Grade II tumours, which have higher local recurrence rates and lower survival rates than their benign counterparts. The aim of this study is to review the outcome of newly diagnosed patients with atypical meningioma after therapy. Aim: To study the incidence and clinical outcome of patients with atypical meningiomas managed at a tertiary care centre with rural set up in rural area of India. Methods and Materials: We conducted a retrospective review of the medical records of patients having atypical meningiomas who were treated in our hospital between January 2008 to December 2017. Their age, sex, initial presentation, tumor location, tumor size, extent of resection, tumor recurrence or tumor progression, duration of follow up, adjuvant therapy, and outcome were reviewed in detail. Results: There were 34 consecutive patients (19 male and 15 female) having newly diagnosed intracranial atypical meningiomas treated in our hospital between January 2008 and December 2017. Their mean age at diagnosis was 60.81 years. Twenty nine patients (85.29%) underwent total resection of the tumor, whereas five patients (14.71%) had partial resection of their tumors during their first time of surgery. Twenty patients (58.82%) had received adjuvant radiotherapy. 12 patients (35.29%) had tumor progression or recurrence during follow up, and five of them were proved to have malignant transformation to anaplastic meningiomas in the following operations. The mean time to tumor progression or recurrence of these nine patients was 17.67 months. Twenty three patients (67.65%) had a favorable outcome, ten patients (29.41%) had an unfavorable outcome, and we lost one patient (2.94%) due to disease progression. Conclusion: Surgery remains the standard treatment for atypical meningioma, and postoperative adjuvant radiotherapy is still controversial especially to those who undergo total surgical resection of the tumors. Our study reveals that early postoperative adjuvant radiotherapy seems to play a role in local control. Atypical meningioma can have malignant transformation to anaplastic meningioma, so aggressive treatment and regular follow up are essential to manage this particular tumor.
Authors and Affiliations
Milan K. Senjaliya, Ankur Bhupendrakumar Pachani, Mayur Mhatre, Parth D. Lalakia
Keywords
Related Articles
- EP ID EP540208
- DOI 10.21276/ijmrp.2018.4.2.072
- Views 53
- Downloads 0
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