A Review: Methods of Drug Targeting to the Brain
Journal Title: Indo American Journal of Pharmaceutical Research - Year 2011, Vol 1, Issue 5
Abstract
Treating central nervous system diseases is very challenging because of the presence of a variety of formidable obstacles that obstruct drug delivery. The brain is very complicated as well as fragile organ and Nature has been played a very efficient role to protect it. The brain is protected from many toxic substances and various chemicals by the presence of two barriers namely blood brain barrier (BBB) and blood cerebrospinal fluid barrier (BCSFB). Various routes of drug targeting to the brain now become an important tool in the pharmaceutical field because of many complicated disease of the brain like Alzheimer, Huntington disease, epilepsy etc. Therefore various routes like craniotomy, osmotic disruption, colloidal drug delivery, intranasal route of administration and nanotechnology have been proposed to favors brain drug delivery. Novel drug delivery is the decisive part of this review. This review includes general methods that can enhance drug delivery to the brain and discussed the appropriate route by which such a drug delivery can be possible.
Authors and Affiliations
Shailesh Shah, A. K Seth, Nirmal Shah, Tejas Ghelani, Sahin P Chauhan
Keywords
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