A Review: Methods of Drug Targeting to the Brain
Journal Title: Indo American Journal of Pharmaceutical Research - Year 2011, Vol 1, Issue 5
Abstract
Treating central nervous system diseases is very challenging because of the presence of a variety of formidable obstacles that obstruct drug delivery. The brain is very complicated as well as fragile organ and Nature has been played a very efficient role to protect it. The brain is protected from many toxic substances and various chemicals by the presence of two barriers namely blood brain barrier (BBB) and blood cerebrospinal fluid barrier (BCSFB). Various routes of drug targeting to the brain now become an important tool in the pharmaceutical field because of many complicated disease of the brain like Alzheimer, Huntington disease, epilepsy etc. Therefore various routes like craniotomy, osmotic disruption, colloidal drug delivery, intranasal route of administration and nanotechnology have been proposed to favors brain drug delivery. Novel drug delivery is the decisive part of this review. This review includes general methods that can enhance drug delivery to the brain and discussed the appropriate route by which such a drug delivery can be possible.
Authors and Affiliations
Shailesh Shah, A. K Seth, Nirmal Shah, Tejas Ghelani, Sahin P Chauhan
Keywords
Related Articles
- EP ID EP221908
- DOI -
- Views 117
- Downloads 0
Matrix Tablets as Controlled drug delivery systems
From the point of patient compliance, dosage regimen of an orally administered drug may be considered to be optional when the therapeutic effects are maintained for the desired duration of the treatment at the lowest fre...
PHARMACOVIGILANCE PROGRAMME IN INDIA PRESENT CIRCUMSTANCE AND ITS PERSPECTIVES
Adverse drug reaction (ADR) is defined as any response to a drug which is harmful and unintended, and which occurs at doses normally used in man for prophylaxis, diagnosis, or therapy of disease, or for the modification...
FORMULATION AND EVALUATION OF GASTRO-RETENTIVE FLOATING TABLETS OF ATENOLOL
Abstract The purpose of the present study was to develop gastro-retentive floating tablet of Atenolol. It is a beta-adrenoreceptor antagonist (beta-blocker) used in the treatment of hypertension and angina pectoris. It i...
PHARMACOLOGICAL PROPERTIES OF FERONIA LIMONIA FRUIT PULP – A REVIEW
Abstract Current research on drug development has emphasized on traditional uses of herbal constituents which were practiced in ancient times. Many parts of Feronia limonia were prescribed for diseases in ancient medicin...
ANAESTHESIA-THE PRIME IMPORTANCE OF SURGERY & FASTING REQUIREMENTS REVIEW
Abstract Anesthesia is temporarily induced loss of sensation. It includes -analgesia(loss of pain), amnesia(loss of memory),unconsciousness (reversible loss of consciousness that is coma not sleep), paralysis(muscle rela...