A REVIEW ON ALZHEIMER'S DISEASE (A. D.)
Journal Title: Journal of Drug Discovery and Therapeutics - Year 2013, Vol 1, Issue 6
Abstract
Major depression in late life and Alzheimer’s disease (AD) are disorders of enormous and increasing public health significance. In addition to early physical and intellectual challenges, individuals with Down syndrome are at a high risk for developing the symptoms characteristic of Alzheimer’s. People with Down syndrome develop the two hallmarks of Alzheimer’s disease amyloid plaques and tau tangles in their 30s and 40s. Due to improved clinical care, people with Down syndrome are now regularly living into their sixth decade of life, causing many to develop dementia due to Alzheimer’s. The high incidence of the symptoms characteristic of Alzheimer’s in people with Down syndrome is thought to be due to the extra copy of chromosome 21, which contains the gene that encodes the amyloid precursor protein (APP). APP is cleaved to form the amyloid-beta peptide; the primary component of plaques. It has been presumed that the extra copy of the gene produces an abnormally high amount of amyloid-beta. The cholinergic hypothesis was initially presented over 20 years ago and suggests that a dysfunction of acetylcholine containing neurons in the brain contributes substantially to the cognitive decline observed in those with advanced age and Alzheimer’s disease (AD).
Authors and Affiliations
M. A. Chaudhari*| Shelino Education Societys, Arunamai College of Pharmacy, Mamurabad, Jalgaon-India, P. V. Sapkale| Shelino Education Societys, Arunamai College of Pharmacy, Mamurabad, Jalgaon-India, Megha Sahu| Shelino Education Societys, Arunamai College of Pharmacy, Mamurabad, Jalgaon-India
Keywords
Related Articles
- EP ID EP1412
- DOI -
- Views 495
- Downloads 31
Emerging drug discovery paradigm in non small cell lung cancer: pharmacophore modeling, atom-based 3D- QSAR and virtual screening of novel EGFR inhibitors
EGFR is a significant drug target approached in the domain of the wide prevailing cancer type, non- small cell lung cancer and search for its potent inhibitor is an emerging opportunity in cancer drug discovery. Computat...
JAHN-TELLER DISTORTIONS: A NEW STRATEGY IN QUANTUM MECHANICS
The concepts of the Jahn-Teller effect and vibronic coupling are being applied to more and more systems in both chemistry and physics. Aspects of structural chemistry such as the distortion of the nuclear framework to a...
Therapeutic impact of garden cress seeds incorporated ladoo among the selected anaemic adolescent girls (12-15 years)
Adolescents are the important segments of the global population. Their well being and the active participation are the fundamental needs for the development of the society. Nutritional problems of adolescent girls are co...
"PROSPECTIVE ANALYSIS OF PREVALENCE AND EFFECT OF LIVER DISEASES IN TYPE II DIABETES PATIENTS: A CROSS SECTIONAL, OPEN LABEL, SINGLE CENTRIC, PILOT STUDY”
That Patients Who has a Liver disease, May because of type 2 diabetes .In cirrhosis Patients diabetes may be occur. In diabetic patients cirrhosis may be occur diabetic play an important role of liver disease. In Diabeti...
Solvent evaporation matrix erosion method: a novel approach for floating microsphere development
Floating drug delivery system is one of the novel drug delivery system. Floating drug delivery system has a bulk density less than gastric fluids and thus it remains buoyant in the stomach without affecting gastric empty...