A REVIEW ON ALZHEIMER'S DISEASE (A. D.)

Journal Title: Journal of Drug Discovery and Therapeutics - Year 2013, Vol 1, Issue 6

Abstract

Major depression in late life and Alzheimer’s disease (AD) are disorders of enormous and increasing public health significance. In addition to early physical and intellectual challenges, individuals with Down syndrome are at a high risk for developing the symptoms characteristic of Alzheimer’s. People with Down syndrome develop the two hallmarks of Alzheimer’s disease amyloid plaques and tau tangles in their 30s and 40s. Due to improved clinical care, people with Down syndrome are now regularly living into their sixth decade of life, causing many to develop dementia due to Alzheimer’s. The high incidence of the symptoms characteristic of Alzheimer’s in people with Down syndrome is thought to be due to the extra copy of chromosome 21, which contains the gene that encodes the amyloid precursor protein (APP). APP is cleaved to form the amyloid-beta peptide; the primary component of plaques. It has been presumed that the extra copy of the gene produces an abnormally high amount of amyloid-beta. The cholinergic hypothesis was initially presented over 20 years ago and suggests that a dysfunction of acetylcholine containing neurons in the brain contributes substantially to the cognitive decline observed in those with advanced age and Alzheimer’s disease (AD).

Authors and Affiliations

M. A. Chaudhari*| Shelino Education Societys, Arunamai College of Pharmacy, Mamurabad, Jalgaon-India, P. V. Sapkale| Shelino Education Societys, Arunamai College of Pharmacy, Mamurabad, Jalgaon-India, Megha Sahu| Shelino Education Societys, Arunamai College of Pharmacy, Mamurabad, Jalgaon-India

Keywords

Related Articles

Recent applications of nanodevices

Although the "war on cancer and other disease like AIDS" is now in its fourth decade and despite much progress has been made in categorizing the environmental causes and cellular and molecular biological basis for this d...

DEVELOPMENT OF SUSTAINED RELEASE DOSAGE FORM OF GLICLAZIDE

The main aim of present work was to prepare solid dispersion of poorly water soluble drug Gliclazide to enhance its in-vitro dissolution rate and aqueous solubility of drug. Gliclazide is a second generation of hypoglyce...

FORMULATION AND EVALUATION OF SUSTAINED RELEASE TABLETS OF LABETALOL HYDROCHLORIDE USING HYDROPHILIC POLYMERS

Labetalol hydrochloride is used in treatment of hypertension. It has a short half life and undergoes extensive first pass metabolism. In the present study, labetalol hydrochloride 100 mg controlled release matrices were...

FLOATING DRUG DELIVERY SYSTEM: A REVIEW

Floating drug delivery systems (FDDS) was to organize the recent journalism with unique focus on the principal mechanism of floatation to achieve gastric retention. The recent developments of FDDS including the physiolog...

EVALUATION OF SEED OIL OF ZANTHOXYLUM ARMATUMFOR ANTIMICROBIAL ACTIVITY

Essential oils have proved to possess valuable antimicrobial and antimicrobial activity. The present work aims at finding out potential of essential oils whose antimicrobial activities have not been fully explored. The r...

Download PDF file
  • EP ID EP1412
  • DOI -
  • Views 497
  • Downloads 31

How To Cite

M. A. Chaudhari*, P. V. Sapkale, Megha Sahu (2013). A REVIEW ON ALZHEIMER'S DISEASE (A. D.). Journal of Drug Discovery and Therapeutics, 1(6), 29-42. https://europub.co.uk/articles/-A-1412