A Review on Biomedical Applications of Polymeric Nanoparticles
Journal Title: Drug Designing & Intellectual Properties International Journal - Year 2018, Vol 2, Issue 3
Abstract
Splendid achievements have been made in management of disease through invention of drugs over past decade. The present conventional drug delivery systems often have side-effects and complications due to their wide distribution throughout the body fluids. The localization of drug action in injured tissue is a promising way to solve this problem. The objective of drug targeting is to achieve a desired pharmacological response at a selected site without undesirable interaction at other sites. This is especially important in cancer chemotherapy and rheumatoid arthritis treatment. Recently invention of drugs has been generated by various drug delivery systems like microspheres, liposomes, noisomes, nanocapsules and nanoparticles. Among all colloidal drug carriers’ nanoparticles are gaining more popularity because of their stability, easy preparation, for achieving reduced toxicity, for increased drug efficacy & site targeted action. Nanoparticulation is a very useful strategy towards targeted drug delivery and also for enhancement of bioavailability of low soluble drugs. In this article nanoparticles preparation methods and their biomedical applications were discussed in detail. Nanotechnology has achieved breakthrough in therapeutics, bioengineering, diagnostics, imaging, and optics in recent vintage [1]. The development of nanosystems by tailoring the macromolecules is the recent topic of interest. As nanoparticles possess extraordinary, often tunable properties dramatically different from the bulk materials, such as high surface to volume ratio, particle size and so forth there is an enormous demand for the tailor-made functional nanoparticle systems. Inorganic, organic or hybrid nanoparticular materials are used in various applications fields as medicine, pharmaceuticals, analytics, catalysis, coating, and several others. Nanoparticles are efficient and versatile devices for drug delivery as they can improve crucial properties of a drug entity such as solubility, pharmacokinetic, biodistribution and in vivo stability [2]. Due to their tailoring properties they can overcome physiological barriers and can help to guide their payload to specific cells or intercellular compartments. By which side effects can be minimized and therapeutic benefits of a drug can be increased. By virtue of their small size and by functionalizing their surface with polymers and appropriate ligands, polymeric nanoparticles can also be targeted to specific cells and locations in the body.
Authors and Affiliations
A Krishna Sailaja
Keywords
Related Articles
- EP ID EP588779
- DOI 10.32474/DDIPIJ.2018.02.000140
- Views 170
- Downloads 0
Ethnomedicobotany: People Health through Wild Plant Resources
Ethnomedicine is an area of research that deals with medicines derived from plants, animals and minerals etc. and used in the treatment of different human and veterinary ailments. Ethnomedicines includes indigenous belie...
Science and War Through the Ages
In all animal species competition between individuals is presented to obtain mainly food and reproduction; When there are not enough satisfiers, there are disputes that usually stop when there is a winner, without indivi...
Successively Substituting an Additional 4-(2-Aminoethyl) Aniline Group in Fabricated Isoindoline-1,3-Dione Scaffold Enhances the Antimicrobial Potency: Part II of Research
The irrational use of antimicrobial agents for several decades has led to the drug-resistance among the patient population. Overcoming the present drug-resistance is a major challenge for modern day scientists. In order...
Current Challenges and Obstacles to Drug Development for Chagas Disease
Chagas disease is a protozoan infection which was first identified more than one hundred years ago. But even now, drugs to treat the latent and chronic phases of the disease are not available. The success of a drug desig...
Would Hydroxychloroquine Be A New Promising Drug in Managing Antiphospholipid Syndrome?
Once Antiphospholipid syndrome (APS) is diagnosed, risk profile of the patient will impact its management whether there was a previous thrombotic event or not, association with other autoimmune disorders, presence of oth...