A Review on Complications of the Prolonged Use of Proton Pump Inhibitors (PPIs) and Presenting a Case of Barrett’s Esophagus
Journal Title: Journal of Advanced Research in Medicine - Year 2018, Vol 5, Issue 4
Abstract
Background: Gastroesophageal reflux disease (GERD) is the most common among gastric disorders and treated by antacids especially proton pump inhibitors (PPIs). Though symptoms are reported to be controlled by PPIs, however the complications like barrettes esophagus, Cancers at GE junction are not studied and reported extensively. In view of symptomatic relief, the long, non-supervised, over the counter medication use has increased. Safety of such long-term has been attempted with the review of available evidence and presentation of a case. Aim: To update available literature on the long-term use of PPIs and possible mechanisms behind adverse events. Materials and Methods: A case of Barrette’s esophagus was presented, with long-term use of PPIs. Detailed history taking of the case was done and another evidence synthesis was done on the effects of the long and short-term use of PPIs. The literature search using Medline, Scopus, Scholar on adverse effects of the use of PPIs was done which were language and date unrestricted. Results: Studies report many adverse effects on short-term (up to 5 years of use, namely: clostridium associated diarrhea, bacterial peritonitis, cholecystitis, pyogenic liver, liver cirrhosis, pneumonia, esophageal inflammations, nocturnal breakthrough acid reflux, interstitial nephritis, drug interaction and nutritional deficiencies mainly of Vitamin B 12 and iron) and long-term use, namely: Concomitant dyspepsia, Barrettes esophagus, osteoporosis, dementia, hypomagnesia, cancers at GE junction. Conclusion: The health care providers and community should be made cautious, larger cohort observational studies are also recommended for more evidence.
Authors and Affiliations
Dr. Neeta Kumar
Keywords
Related Articles
- EP ID EP472712
- DOI 10.24321/2349.7181.201820
- Views 103
- Downloads 0
Overlap Syndrome of Autoimmune Hepatitis and Primary Biliary Cirrhosis: A Clinical Enigma
“Overlap syndrome” is a term used to describe variant forms of autoimmune hepatitis (AIH) which present with characteristics of AIH and primary biliary cirrhosis (PBC) or primary sclerosing cholangitis (PSC). Patients wi...
Maternal and Fetal Outcome in Deranged Liver Function Test and Jaundice Complicating Pregnancy: A Prospective Study
Background: The objective of the study was to study maternal and fetal outcome in pregnancy complicated with deranged liver function test and jaundice. Methods: Total 150 antenatal patients with clinical or laboratory...
Disseminated Histoplasmosis in an Immunocompetent Host Presenting as Pyrexia of Unknown Origin (PUO)
Histoplasmosis is a progressive granulomatous disease caused by intracellular dimorphic fungus Histoplasma capsulatum. The fungus present in the soil infects through inhalational route and can manifest as any of the thre...
Severe Thrombocytosis in Chronic Liver Disease Secondary to Iron Deficiency Anemia: A Case Report
Thrombocytopenia is the commonest haematological abnormality seen in chronic liver disease. Thrombocytosis is of two types: Primary and secondary. In secondary form of thrombocytosis usually there is mild to moderate ele...
Analyzing the Factors for Pre-operative Prediction of Problematic Laparoscopic Cholecystectomy: A Cross-sectional Exploratory Study
Background: Laparoscopic cholecystectomy is considered as the preferred treatment for symptomatic Cholelithiasis. Though laparoscopic cholecystectomies are considered a common surgical intervention, still 1-13% requires...