A review on Mucoadhesive Buccal Patches
Journal Title: International Journal of Research and Development in Pharmacy & Life Sciences (IJRDPL) - Year 2017, Vol 6, Issue 4
Abstract
The oral cavity is an attractive site for the delivery of drugs. Through this route it is possible to realize mucosal (local effect) and transmucosal (systemic effect) drug administration. In the first case, the aim is to achieve a site-specific release of the drug on the mucosa, whereas the second case involves drug absorption through the mucosal barrier to reach the systemic circulation.Absorption through the buccal mucosa overcomes premature drug degradation due to the enzyme activity and pH of gastro intestinal tract, avoids active drug loss due to presystemic metabolism, acid hydrolysis and therapeutic plasma concentration of the drug can be rapidly achieved. The adhesive properties of such drug delivery platforms can reduce the enzymatic degradation due to the increased intimacy between the delivery vehicle and the absorbing membrane. However, per oral administration of drugs has disadvantages such as hepatic first pass metabolism and enzymatic degradation within the GI tract, that prohibit oral administration of certain classes of drugs especially peptides and proteins. Consequently, other absorptive mucosa is considered as potential sites for drug administration. Transmucosal routes of drug delivery offer distinct advntages over per oral administration for systemic drug delivery.
Authors and Affiliations
Aspee Singh| Institute of Pharmacy, Bundelkhand University Jhansi, Uttar Pradesh, India, Upendra Kumar Sharma| Institute of Pharmacy, Bundelkhand University Jhansi, Uttar Pradesh, India, S. K. Prajapati| Institute of Pharmacy, Bundelkhand University Jhansi, Uttar Pradesh, India
Keywords
Related Articles
- EP ID EP16020
- DOI http://dx.doi.org/10.21276/IJRDPL.2278-0238.2017.6(4).2654-2
- Views 427
- Downloads 16
In-vitro evaluation of Anti-bacterial and Anti-fungal activity of different Explant extracts of Thespesia populnea L.
Antibacterial and antifungal activity of leaf, bark, flower and seed extracts of Thespesia populnea L.was investigated. The antibacterial activity and antifungal activity was tested against both gram-positive and gram-...
Anti-stress effects of cinnamon (Cassia zelynicum) bark extract in cold restraint stress rat model
The present study aims at investigating the anti-stress effects of cinnamon (Cassia zelynicum) bark extract in cold restrained stress (CRS) model. The cinnamon anti-stress effect was characterized using ulcer scoring, a...
Formulation and evaluation pf Phospholipid complex of Green Tea Polyphenol
OBJECTIVE: Phospholipid complexes are formulated to improve absorption, bioavailability and stability of herbal product. There are many herbal extracts having excellent in-vitro activity but less in-vivo activity becau...
Evaluation of natural oils for the development of cheap and sustainable solution for mosquito problem in the poor community
Mosquitoes and their increasing number are responsible for causing millions of deaths around the world. Another important aspect is global warming that has already altered the distribution of vector borne diseases (IPC...
AN OVERVIEW ON MICROWAVE MEDIATED SYNTHESIS
Microwave-assisted organic synthesis is an enabling technology for accelerating drug discovery and development processes. Microwave organic synthesis opens up new opportunities to the synthetic chemist in the form of ne...