A review on solid dispersion and latest approaches used to improve solubility of poorly water soluble drugs
Journal Title: World Journal of Pharmaceutical Sciences - Year 2016, Vol 4, Issue 10
Abstract
In the present day solubility of drugs in GIT fluids becomes necessary for the preparation of solid unit dosage forms of drugs. Otherwise if the drug has poor solubility then the drug does not show its effect properly in the body. So, solubility is a main aspect in the formulation of unit doses. Various methods like Lyophilization (Freeze drying process), Super critical fluid technology, Nanotechnology, Liquisolid compact technology, Self-emulsifying agents (SMEDDS) etc. are used to improve the solubility and dissolution rate of poorly water soluble drugs.
Authors and Affiliations
Ramanpreet kaur
The potential role of sitagliptin as an oral treatment regimen for type I diabetes mellitus
Type 1 diabetes mellitus (T1D) has become an emerging worldwide epidemic with growing incidence all over the world in the past several decades. Insulin replacement has been the backbone of therapy in T1D which is charact...
Hypoglycemic and Hypolipidemic Effect of Active Compounds (Glucokinin or Plant Insulin) from Bauhina variegate L. in Alloxan Induced Diabetic Mice
Bauhinia variegata L. belongs to the family Leguminosae. This study has employed an in vivo evaluation of leaves (petroleum ether and methanol extract) and methanol extract and flowers extraction in mice at concentration...
Development and validation of a new stability indicating liquid chromatographic method for the simultaneous determination of thiocholchicoside and etoricoxib in combined dosage form
A simple and sensitive stability indicating RP-HPLC method was developed and validated for the simultaneous determination of thiocholchicoside and etoricoxib in combined dosage forms. The separation of thiocholchicoside...
Quantum Dots: A New-fangled Loom in Drug Delivery and Therapeutics
Quantum dots (QDs) are luminescent nanoscale semiconductor crystal with surface chemistry and unique optical properties that make them useful as carriers for traceable targeted delivery and therapeutic applications. QDs...
Nanotechnology for Diabetes: A Review
This review article discusses the potential applications of nanoparticles and BioMEMS as drug delivery systems for diabetes treatment. This manuscript discusses polymeric nanoparticles, oral insulin administration using...