A REVIEW ON SOLID LIPID NANOPARTICLES; FOCUS ON EXCIPIENTS AND FORMULATION TECHNIQUES
Journal Title: International Journal of Pharmaceutical Sciences and Research (IJPSR) - Year 2019, Vol 10, Issue 9
Abstract
Nanotechnology has brought about a significant change in the drug delivery system. A plethora of BCS class II drugs are formulated as solid lipid nanoparticles (SLN) due to its poor solubility and bioavailability and has potential applications in drug delivery system. The formulation of SLN involves use of a different type of surfactants and lipids in different concentrations which has shown a greater impact on various physicochemical parameters such as entrapment efficiency, drug release, particle size, zeta potential, storage and stability of the drug. Apart from its unique size-dependent property, merits and demerits, different excipients characterization technique, scale up, storage and stability are reviewed.
Authors and Affiliations
P. K. Lakshmi et al.
Keywords
Related Articles
- EP ID EP627082
- DOI 10.13040/IJPSR.0975-8232.10(9).4090-99
- Views 125
- Downloads 0
ASSESSMENT OF IN-VITRO ANTICANCER AND ANTIBACTERIAL ACTIVITIES OF CARCHORUS HIRSUTUS PHYTOMEDIATED OPTIMIZED NANOSILVER
The elected work reports for the first time successfully synthesized nanosilver from the aqueous leaf extract of the Carchorus hirsutus plant. Because the phytochemicals within the leaf extract were creditworthy for the...
FORMULATION AND EVALUATION OF pH TRIGGERED IN-SITU OCULAR GEL OF OFLOXACIN
Rapid precorneal elimination of the drug in conventional ophthalmic solution leads to poor bioavailability and less therapeutic response, which can be overcome by the use of in-situ gel forming system that is instilled i...
FTIR SPECTROPHOTOMETRIC METHOD FOR THE SIMULTANEOUS ESTIMATION OF ARTEMETHER AND LUMEFANTRINE IN BULK AND FORMULATIONS
A FTIR method was developed to estimate Artemether and Lumefantrine simultaneously in bulk as well as in formulations. It is based on the measurement of absorption of radiation at the absorption band of ether at 1113.10-...
ANTI-PARKINSON’S ACTIVITY OF SORAFENIB IN 6-OHDA INDUCED RAT MODEL
Studies have shown that sorafenib an anti-cancer agent has a neuroprotective effect. This study evaluated the neuroprotective activity of sorafenib in 6-OHDA induced rat model of Parkinson’s disease. Methods: 6-OHDA was...
EVALUATION OF IMPACT OF MEDICATION RECONCILIATION IN STROKE PATIENTS IN A TERTIARY CARE HOSPITAL
Stroke is a medical condition in which poor blood flow to the brain results in cell death and is the second most common cause of death after coronary artery disease. Stroke patients with added co-morbidities on an averag...