A REVIEW ON SYNTHESIS OF SCHIFF’S BASES OF 2-AMINO 4-PHENYL THIAZOLE
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2011, Vol 2, Issue 6
Abstract
Thiazoles and their derivatives exhibit a wide variety of biological activities like anti diabetic, anti inflammatory, anticonvulsants etc. In the present study we have synthesized some substituted thiazoles. These compounds were evaluated for various biological activities like Anti-diabetic, anti-inflammatory, anti-fungal activity. 2-aminothiazoles are known mainly as biologically active compounds with awide-ranging activity of intermediates in the synthesis of antibiotics and dyes. The extensive synthetic possibilities of these heterocyclic due to the presence of several reaction sites hold promise for the preparation of new thiazoles derivatives and expansion of the range of application of these compounds. Thiazole derivatives were prepared by one-pot procedure by the reaction of haloketones, thiourea and substituted o-hydroxybenzaldehyde under environmentally solvent free conditions.
Authors and Affiliations
Avanish Kumar , Rajesh Kumar
Keywords
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