A review on the use of Bleomycin-Cisplatin-Vinblastine combinations in therapy of testicular cancer
Journal Title: Indian Journal of Research in Pharmacy and Biotechnology - Year 2013, Vol 1, Issue 6
Abstract
Combination chemotherapy with vinblastine plus bleomycin in disseminated testicular cancer was pioneered by Samuels and represented a major therapeutic advance (Samuels ML, 1976). Another milestone in the chemotherapy of testicular cancer was the discovery of the activity of cis-diammine dichloro platinum (CDDP) in germinal neoplasm. Complete response rates between 60-80% have been reported for patients with advanced disease and the vast majority of these patients are cured of their disease as the relapse rates are less than 15% (Robert F, 1983). This discovery has led to a new and better chemotherapeutic combination in the treatment of testicular cancer. For the first time, in a random prospective cooperative group clinical trial evaluating the effectiveness of three Chemotherapy combinations in the treatment of a solid tumor, in which the dose of one drug is the only treatment variable, a clear-cut relationship has been shown for dose of therapy, not only with response and survival, but with an increased potential for cure as well. Their plasma half-lives, pharmacokinetic parameters, toxicities, adverse drug effects were also evaluated in various studies. This combination have been proved better than Bleomycin-cisplatin-etoposide as the former combination masks the toxic effects of bleomycin such as mucositis etc. Thus we conclude that this combination is a safer one with a good therapeutic efficacy and reduced toxicity.
Authors and Affiliations
Praveen D, Ranadheer Chowdary P
Keywords
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