A REVIEW REPORT ON LYRICA (PREGABALIN) AS ANTIEPILEPTIC AGENT
Journal Title: Journal of Biological and Scientific Opinion - Year 2013, Vol 1, Issue 4
Abstract
Epilepsy is a chronic disorder of the central nerve system (CNS). It affects 5-10 per 1000 of the general population. There are different types of epilepsies. For the identification of different kinds of epilepsies different test and physical examination will perform by the doctors, further to treatment of this disease the treatment involves surgery and medication. For medication of this disease many kinds of antiepileptic drugs are available which are divided into many chemical classes. Lyrica pregabalin is the new antiepileptic drug which is introduced as an antiepileptic agent in 30th December 2004 by the FDA. It is a structural derivative of the inhibitory neurotransmitter gamma amino butyric acid (GABA). Dizziness and drowsiness are the most common (>10 % patients) adverse effect of pregabalin. A hypersensitivity to pregabalin or other component of the product may develop, resulting in an unfavorable interaction with the body. Pregabalin cross the blood–brain barrier in mice, rats, and monkeys. Approximately 98 % of the radioactivity recovered in the urine was unchanged pregabalin. N-methyl is the major metabolite of pregabalin. It has been assigned to pregnancy category ‘C’ by the FDA. Pregabalin is also used off-label for the treatment of chronic pain, neuropathic pain, preoperative pain, and migraine. The maximum dosing regimen is 600 mg/day.
Authors and Affiliations
Sumit Kumar, Swatantra Singh
Keywords
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- EP ID EP136320
- DOI 10.7897/2321–6328.01426
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