A Role of N-Cadherin in Tumor Progression and Prognosis of Epitheliual Malignancy
Journal Title: International Journal of Contemporary Medical Research - Year 2016, Vol 3, Issue 1
Abstract
Epithelial cells typically express E-cadherin, mesenchymal cells express various cadherins, including N-cadherin, R-cadherin and cadherin-11. N-cadherin is also known as neural-cadherin, non-epthelial cadherin or cadherin-2 and CD325. The term cadherin switching usually refers to a switch from expression of E-cadherin to expression of N-cadherin. Several studies from current literature have shown de novo expression, re-expression, up-regulation and down-regulation of N-Cadherin in human tumors and tumoral cell lines like breast cancer, gastric cancer, pancreatic cancer, esophageal cancer, oral cancer, prostate cancer, lung cancer, and urinary system cancer.We focus here on the pattern of N-cadherin expression in these malignant tumors of the epithelial origin to evaluate its critical contribution in tumor progression and prognosis.
Authors and Affiliations
Harish chandra Rai K, Junaid Ahmed
Keywords
Related Articles
- EP ID EP423579
- DOI -
- Views 140
- Downloads 0
Assessment and Comparision of HIV Awareness among Interns of a Private Group of Institutions in Bangalore
Introduction: Human Immunodeficiency Virus (HIV), has become a global havoc to humanity. The first HIV/AIDS case in India was reported in 1986 among sex workers in Chennai. According to National AIDS Control Organization...
Serum Human Chorionic Gonadotropin Level in Pre-Eclamptic and Normotensive Pregnant Women: A Prospective Study
Introduction: Pre-eclampsia causes the various fetal and maternal complications. Can cause 8-10% maternal deaths in india and 5-10% in western countries. Human Chorionic Gonadotropin is composed of alfa and beta subunit,...
Dermatology Inpatient Consultations: A One Year Experience from a Tertiary Care Centre in Northern India
Introduction: Hospital inpatient consultations are important for the smooth functioning of healthcare in tertiary hospitals. Dermatology inpatient consultations have gained significance due reduction in dermatology inpat...
A Comparative Study Between Virtual Bronchoscopy and Fibreoptic Bronchoscopy in Diagnosis of Lung Lesions
Introduction: Fibreoptic bronchoscopy (FOB) remains the best modality for evaluation of endoluminal and mucosal lesions; however, endoscopy yields no information about the extent of extraluminal disease or airway patency...
A Case of Intra Muscular Sodium Stibogluconate Induced Hypokalemia
Introduction: Cutaneous leishmaniasis has been detected in the Kashmir valley since the last decadea. The pentavalent antimonials meglumine antimoniate and sodium stibogluconate are the gold standard of treatment. Case R...