A Role of N-Cadherin in Tumor Progression and Prognosis of Epitheliual Malignancy
Journal Title: International Journal of Contemporary Medical Research - Year 2016, Vol 3, Issue 1
Abstract
Epithelial cells typically express E-cadherin, mesenchymal cells express various cadherins, including N-cadherin, R-cadherin and cadherin-11. N-cadherin is also known as neural-cadherin, non-epthelial cadherin or cadherin-2 and CD325. The term cadherin switching usually refers to a switch from expression of E-cadherin to expression of N-cadherin. Several studies from current literature have shown de novo expression, re-expression, up-regulation and down-regulation of N-Cadherin in human tumors and tumoral cell lines like breast cancer, gastric cancer, pancreatic cancer, esophageal cancer, oral cancer, prostate cancer, lung cancer, and urinary system cancer.We focus here on the pattern of N-cadherin expression in these malignant tumors of the epithelial origin to evaluate its critical contribution in tumor progression and prognosis.
Authors and Affiliations
Harish chandra Rai K, Junaid Ahmed
Keywords
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