A SENSITIVE METHOD FOR DETECTING DINUCLEOTIDE ISLANDS AND CLUSTERS THROUGH DEPTH ANALYSIS
Journal Title: Romanian Journal of Diabetes Nutrition and Metabolic Diseases - Year 2011, Vol 18, Issue 2
Abstract
The field of bioinformatics is an essential asset for modern biology. In recent years, after the appearance of GWS (Genome Wide Scan) studies, powerful bioinformatics methods have been developed. In order to understand the genetic basis of various diseases, especially polygenic diseases (diabetes, obesity and vascular disease), we have implemented a dynamic method named "in-depth analysis" to detect and interpret CpG islands, CpG clusters and other dinucleotide structures. In-depth analysis is made through repeated tests with different dinucleotide thresholds. GCLUSTER is our design for "in-depth analysis". We tested GCLUSTER with randomly generated DNA sequences, multiple genes from Homo sapiens and several types of viral genomes.
Authors and Affiliations
Paul Gagniuc, Dănuţ Cimponeriu, Nicolae Mircea Panduru, Monica Stavarachi, Mihai Toma, Constantin Ionescu-Tîrgovişte, Lucian Gavrilă
Keywords
Related Articles
- EP ID EP145068
- DOI -
- Views 89
- Downloads 0
REMISSION PERIOD IN CHILDREN AND ADOLESCENTS WITH TYPE 1 DIABETES
Type 1 diabetes mellitus (DM) is characterized by a progressive autoimmune destruction of pancreatic beta cells, process that can be influenced by clinical and metabolic factors. The objective was to identify those facto...
FFECT OF LIRAGLUTIDE ON CARDIOVASCULAR RISK FACTORS AND FUNCTION
Cardiovascular disease is the major cause of death in diabetes. This results from a cluster of risk factors, including high glucose, obesity, hypertension and dyslipidaemia. Liraglutide is the first native GLP-1 analogue...
The Impact Of An Educational Program In The Management Of Patients With Chronic Hepatitis C
Introduction: This study was designed to measure the impact of lifestyle changes, involving a diet therapy and physical exercises in patients with chronic hepatitis C (CHC). Methods: The study was conducted during Januar...
THE VALUE OF DIFFERENT ANTHROPOMETRIC VARIABLES IN ASSESSING CARDIOMETABOLIC RISK
Objective. To investigate which anthropometric parameter best correlates with modifications in blood glucose and blood pressure (BP). Material and method. 135 subjects were included in the study. We measured weight, heig...
SCREENING AND DIAGNOSTIC CRITERIA FOR GESTATIONAL DIABETES MELLITUS – CHANGES WORLDWIDE OVER TIME
Gestational diabetes mellitus (GDM) is defined as a glucose intolerance with first onset or first recognition during pregnancy. GDM is associated with higher incidence of maternal and fetal complications. Screening for G...