A Short Review on Biological Potential Thiopyridazine Analogues
Journal Title: UNKNOWN - Year 2018, Vol 8, Issue 9
Abstract
Pyridazinone/thiopyridazinone derivatives represent one of the most active classes of compounds possessing a wide spectrum of biological activities such as cardiovascular properties, anti-inflammatory, analgesic, antidiabetic, antiviral, anticancer, antimicrobial, anticonvulsant and other biological activities. Some pyridazinthiones were tested for biological activities. Various pyridazinone/thiopyridazine derivatives were exhibited anticonvulsant activity against maximal electroshock seizure test, various pyridazine-thione derivatives were exhibited antitumor activity and some thiopyridazines were exhibited anti-microbial activity against various strains like Staphylococcus aureus, Escherichia coli, Bacillus subtillis and Candida albicans. Tricyclic ring system, pyridazino[6,1-b]quinazolin-10-ones, benzimidazolo-pyridazine thione, and 1,2,4-benzotriazino-pyridazinethione along with imidazo-[1,2-b]-pyridazinethione, 1,2,4-triazolo[4,3-b] pyridazine-thione derivatives were exhibited antimicrobial activity against gram-positive and gram negative bacteria as well as fungi.
Authors and Affiliations
Mohammad Asif
Keywords
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