Synthesis and Antibacterial Activity of Novel Benzimidazole Linked 1,3,4-Oxadiazole Derivatives
Journal Title: UNKNOWN - Year 2019, Vol 9, Issue 2
Abstract
With an intention to develop potent antimicrobial agents from the source of benzimidazole- 1,3,4-oxadiazole combined heterocyclic derivatives, novel 6-Chloro-2-(2-(5-(substituted phenyl)-1,3,4-oxadiazol-2-yl)ethyl)- 1H-benzo[d]imidazole derivatives were synthesized using condensation reaction of 3-(6-chloro-1H-benzo[d] imidazol-2-yl)propane hydrazide and benzoic acids as key step in presence of POCl3. All newly synthesized target compounds (4a-4n) were characterized by 1H NMR, Mass and IR spectral studies and were screened for their antibacterial activity with two bacterial pathogens (Gram positive: Bacillus subtilis, Gram negative: Escherichia coli) which confirmed that compounds 4a, 4b, 4d, 4g, 4h and 4n have potent activity against B. subtilis as compare with gentamicin at concentration 500 μg/mL. We hope that this study may helpful for further optimization in finding of lead antimicrobial from the origin of benzimidazole linked oxadiazole derivatives.
Authors and Affiliations
Bala Guraiah Mothukuri, Triloknadh Settypalli, Nagaraju Begari, Vijaya Kumari Dalavai, Venkata Rao Chunduri
Keywords
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