Rapid Access Synthesis of Quinoline, Chromene, Thiochromene Benzimidazol-Ylideneamines and Benzimidazolones via Traceless Tandem Transformation Under Microwave Irradiation on Ionic Liquid Support
Journal Title: UNKNOWN - Year 2018, Vol 8, Issue 8
Abstract
A fast and efficient protocol have explored to access the various benzimidazole constituted quinoline, chromene, thiochromenyldenamines and ones under microwave irradiation on ionic liquid support. Ionic liquid supported 4-floro3-nitrobenzoicacid has been used as a structural building block to generate these structural frameworks. After subsequent transformation the benzimidazole constituted cyanoacetic acid has been used as a molecular scaffold to generate various structural motifs. By taking the benzimidazole constituted cyanoacetic acid treated with various 2-substituted hydroxyl, amino and thiobanzaldehydes in order to get the described decorated structural scaffolds in the presence of organic base such as triethylamine. Under the same reaction conditions by leave the product and the cleavage of product from the support occurred sequence of transformations in traceless tandem manner. The same reaction under the hydrous conditions the imine hydrolysis leads to formation of quinoline, chromene, thiochromene benzimidazolones was described. The final compounds have been obtained high yield and purity making this procedure facile, practical, and rapid to execute.
Authors and Affiliations
Suman Thummanagoti, Chih Hau Chen, Chung Ming Sun
Keywords
Related Articles
- EP ID EP673126
- DOI -
- Views 57
- Downloads 0
Essential Oil Profile of Wild and Cultivated Accession of Cymbopogon schoenanthus (L.) from Uttarakhand Region
The chemical composition of the essential oils of Cymbopogon schoenanthus (L.) was investigated by GC and GC/MS study. Cis-sabinene hydrate was found as the major component which varies from...
Synthesis and Biological Evaluation of Novel 1,4-Disubstituted 1,2,3-Triazoles and Bis 1,2,3-Triazoles as Anti-Bacterial Agents
A library of novel 1,4-disbustituted 1,2,3-triazoles 3a-3k was prepared by using Click-chemistry concept. In this 1,3-dipolar cycloaddition, the 3-methoxy-4-(prop-2-yn-1-yloxy)benzaldehyde (1) was used as alkyne partner...
Synthesis and Antioxidant Activity of Mixed Ligand Complex of Quercetin and Aspartic Acid with Cobalt(II)
Mixed ligand complexes are widely used in the field of pharmaceutical science due to their curing nature to various diseases. The present study was aimed to synthesize and explore the antioxi...
1-Aminobenzotriazole: A Mechanism-Based Cytochrome P450 Inhibitor and Probe of Cytochrome P450 Biology
1-Aminobenzotriazole (1-ABT) is a pan-specific, mechanism-based inactivator of the xenobiotic metabolizing forms of cytochrome P450 in animals, plants, insects, and microorganisms. It has been widely used to investigate...
In Vivo and In Vitro Anti-trypansomal Evaluation of Crude Methanolic Extracts of Crotalaria albicaulis and Cistanche phelypaea against Trypanosoma evansi
Camel trypanosomiasis is a major disease of economic importance in Ethiopian Somali Regional State, Ethiopia. Local people use the leaves of Crotalaria albicaulis and Cistanche phelypaea to treat this disease and complem...