A six-month follow-up study to evaluate changes of pulmonary function test in Category I pulmonary tuberculosis treatment completed patient
Journal Title: National Journal of Physiology, Pharmacy and Pharmacology - Year 2018, Vol 8, Issue 1
Abstract
31National Journal of Physiology, Pharmacy and Pharmacology 2018 | Vol 8 | Issue 1RESEARCH ARTICLEA six-month follow-up study to evaluate changes of pulmonary function test in Category I pulmonary tuberculosis treatment completed patientPrashant J Patil, Sarika P PatilDepartment of Physiology, Shri Bhausaheb Hire Government Medical College, Dhule, Maharashtra, IndiaCorresponding to: Sarika P Patil, E-mail: durgapjp@gmail.comReceived: June 25, 2017; Accepted: July 21, 2017ABSTRACTBackground: Tuberculosis (TB) is being a preventable and curable disease that it accounts the world-wide problem. India is one of the TB burden countries. Clinical manifestation of pulmonary TB leads pulmonary dysfunction with functional changes in the lung tissue. Treated patients are free from mycobacterium and considered cured, but the restoration of lungs function in these patients is also needed. Aims and Objectives: This study plans to evaluate and compare the pulmonary function test (PFT) parameters immediately, 3 months and 6 months after the completion of TB treatment and assess its severity. Materials and Methods: By convenient sampling, 118 voluntarily participated pulmonary TB-treated patients completing Category I regimen. PFT during three intervals after the completion of full course of antitubercular drugs was evaluated. Spirometry was done in sitting position according to the American Thoracic Society (ATS) recommendation and interpretation of the results was done. Results: Male-to-female proportion of the pulmonary TB patients was 56.8% versus 43.2%, respectively, within 22-65 years. Maximum patients, that is, 39% were within 31-40-year-age group. Immediate after completion of the treatment, 7.6% had symptoms of exertion dyspnea which were not on follow-up visits. The percent predictive values of the PFT were marginally above the impairment values. There was statistically significant difference mean forced vital capacity (FVC) (P < 0.001), forced expiratory volume at one second/FVC ratio percentage (P < 0.01), peak expiratory flow rate (P < 0.05), and maximal voluntary ventilation (P < 0.01) at the three intervals. Pulmonary function results were normal in 89.8% of patients immediately after the completion of TB treatment, in 91.5% at 3 months and 88.1% at 6 months. Impaired pulmonary function values were in 10.2% of patients at immediate, 8.5% at 3 months, and 11.9% patients at 6 months after completion of TB treatment. The 6-month PFT findings in 6.8% had obstructive changes, 3.4% had restrictive, and 1.7% with mixed PFT changes. Conclusion: There is the presence of pulmonary functional limitations in Category I TB-treated patients. Values for PFT were still lower in few patients even after completion of 6 months of treatment for Category I pulmonary TB.
Authors and Affiliations
Prashant J Patil, Sarika P Patil
Keywords
Related Articles
- EP ID EP449658
- DOI 10.5455/njppp.2018.8.0724121072017
- Views 38
- Downloads 0
Evaluating the clinical applications of visual evoked potentials in patients presenting with visual dysfunctions - A retrospective study
Background: The clinical applicability of visual evoked potential (VEP) tests has been progressively extending in neuro-ophthalmological workups. The role in monitoring and follow-ups are emerging as even more useful app...
A pilot study to evaluate the effect of HAART on gonadal dysfunction in male HIV patients
Background: Derangement of gonadal functions has been reported in association with HIV infection, but data from Indian population are not sufficient. Aims & Objective: To evaluate the effect of highly...
Assessment of ventilatory disorders in artisans exposed to wood dust
Background: Wood dust is produced at virtually all stages of the wood industry. The most important wood-related risks are chemical hazards with the use of toxic, allergenic, and carcinogenic products which may alter resp...
Evaluation of efficacy of the fixed vs unfixed combination of latanoprost and timolol in patients of open-angle glaucoma and ocular hypertension insufficiently controlled on timolol and latanoprost monotherapy
Background: Glaucoma is a term describing a group of ocular disorders with multifactorial etiology united by a clinically characteristic intraocular pressure (IOP) associated optic neuropathy. Elevated IOP is identified...
Evaluation of analgesic activity of pioglitazone in albino mice
Background: Analgesics selectively relieve pain by acting either on central or peripheral pain pathways. Recently, studies have shown accumulating evidence to implicate N-methyl-d-aspartate receptors (NMDARs) mediation i...