A study comparing six month treatment effects of Intranasal Mometasone, Azelastine and Oral Cetirizine in patients with persistent allergic rhinitis.
Journal Title: GJRA-Global Journal For Research Analysis - Year 2015, Vol 4, Issue 8
Abstract
Objectives: Allergic rhinitis is an allergen induced upper airway inflammatory disease. This one-year study was taken up to compare the efficacy of intranasal azelastine, intranasal mometasone and oral cetirizine in patients of allergic rhinitis during the six months treatment period and in the six month follow up period after treatment cessation. Methods: In this open label, three-arm study, patients aged 18- 60 yrs, with at least one month history of persistent allergic rhinitis were enrolled and eligible patients were randomized into Group I -Intranasal Azelastine/ Group II-Intranasal Mometasone/ Group III- Oral Cetirizine. Primary outcome measure was reduction in total symptom score at 14 days from baseline. Results: Each group had 15 patients with median baseline symptom scores of 10, 9 and 9 in Groups I, II and III respectively. There was significant reduction in total nasal symptom scores in Group II when compared to Groups I (p<0.01) and III (P<0.0001) and between Groups I & III, the reduction in total nasal symptom scores was non-significant at day 14. The number of recurrent episodes of rhinitis during follow up period were significantly less in group II when compared to Groups I (p<0.0001) and III (p<0.0001) and were significantly less in Group I when compared to Group III (p<0.001). Conclusions: Mometasone nasal spray when used for longer duration despite resolution of symptoms, is effective in prevention of recurrent episodes after treatment cessation, when compared to azelastine nasal spray and oral cetirizine
Authors and Affiliations
Radhika Soanker, Hanumantha Rao AVS, Jayasree Jayasree
Keywords
Related Articles
- EP ID EP594109
- DOI -
- Views 59
- Downloads 0
INTRA OPERATIVE FROZEN SECTION - REALISTIC EXPECTATIONS IN THE CURRENT SCENARIO- EXPERIENCE WITH 135 CASES IN A TERTIARY CARE CENTRE
Aim: To assess the utility of frozen section in this recent scenario of improved patient care Methods: In our study we analysed the efficacy of frozen section in 135 cases over a period of one and half years including th...
A COMPARISON OF ASPIRATION WITH NON ASPIRATION TECHNIQUE IN FINE NEEDLE CYTOLOGY OF THYROID LESIONS
Back ground: Fine needle cytology is a valuable adjunct to preoperative diagnosis of thyroid lesions and it can helps in assessment of benign and malignant condition. Aims and objectives: To compare the efficacy of fine...
ECONOMICAL AND HEALTH CHANGING PROFILE OF GONDALIGA COMMUNITY:A SOCIOLOGICAL STUDY IN KARNATAKA.
In this study entitled “Economical and Health changing prole of Gondaliga Community A Sociological Study in Karnataka” the impact of social change factors on Socio-economic cultural Educational, Religious and Political,...
LEUCORRHOEA: NOT AN INNOCUOUS SYMPTOM.
Background: Leucorrhea is a major problem in gynecological practice. It can be “physiological” or “pathological.” Common pathological causes are infections, cervicitis, atrophy, malignant and premalignant lesions of cerv...
A Study on Customer Brand Awareness on Duroflex Mattress in Hosur City
It is highly unpredictable to know the consumer’s decision to buy a product or not to buy as today's market is more dynamic in nature with more and more product offerings with the short product life cycles. This is becau...