A study of anti-HBS titers following pentavalent immunization (DTWP-HBV-HIB) in term normal weight vs low birthweight infants
Journal Title: MedPulse -International Medical Journal - Year 2019, Vol 6, Issue 1
Abstract
Objective: To compare anti-HBs titers between term low birth weight (1800-2499 g) infants and normal birthweight infants, 6 weeks after last dose of primary immunization with pentavalent vaccine, and to study adverse events following immunization (AEFI) with pentavalent vaccine. Participants: 265 low birth weight (1800-2499g) and 265 normal birth weight (2500-4000g) infants. Monovalent Hepatitis B vaccine was admin is tered within 24 hours of birth followed by three primary doses of pentavalent vaccine at 6, 10 and 14 weeks. Anti-HBs titers were estimated after 6 weeks of third dose of pentavalent vaccine. Adverse events following immunization (AEFI) month were observed for a month after eachdose of pentavalent vaccine. Main outcome measures: Anti HB santi body titers after 6 weeks of primary immunization, and AEFI. Result: 443(83.5%) infants (225 lowbirthweightand218normal birthweight infants) completed the follow-up. Seroprotection against hepatitis B virus was achieved in both groups after pentavalent vaccine administration. Anti HBs GMTs in low birth weight infants (194.8mIU/mL) and normal birth weight in fants (204.2mIU/mL)were comparable (P=0.17).No serious adverse events were observed in either group. Conclusion: Three primary doses of pentavalent vaccine administered along with zerodose of Hepatitis Bv accineat birth provide good sero protection. The vaccine appears to be safe in both low birth weight and normal birth weight in fants born atterm.
Authors and Affiliations
Mani Shankar, Ashok Kumar, Hari Shankar Mishra
Keywords
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- EP ID EP487727
- DOI 10.26611/1004615
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