A Study of AST/ALT Ratio in Metabolic Syndrome
Journal Title: International Journal of Contemporary Medical Research - Year 2017, Vol 4, Issue 1
Abstract
Introduction: Features of metabolic syndrome and non alcoholic fatty liver disease (NAFLD) are strongly associated with one another. NAFLD has also been proposed as a component of metabolic syndrome. Hepatocyte damage as a consequence of hepatic fat accumulation is characterized by the release of aspartate transaminase (AST) and alanine transaminase (ALT) enzymes from damaged liver cells into the blood. AST/ALT ratio can be used to differentiate alcoholic liver disease from NAFLD. The present study aimed to determine AST/ALT ratio in individuals with metabolic syndrome and in healthy controls and to correlate it with the components of metabolic syndrome. Material and methods: 50 subjects with metabolic syndrome and 50 healthy, age and gender matched individuals without features of metabolic syndrome were enrolled for the study. Fasting venous samples collected from the study group were estimated for glucose, AST, ALT, total bilirubin and lipid profile. Results: AST/ALT ratio was significantly lower in individuals with metabolic syndrome when compared to controls (p<0.001). A marked association of metabolic syndrome with decreased AST/ALT ratio was observed with odd’s ratio of 16.6. AST/ ALT ratio also showed a significant negative correlation with waist circumference, blood pressure, fasting blood glucose and triglycerides and a positive correlation with HDL. Conclusion: In the present study, AST/ALT ratio was found to be significantly reduced in subjects with metabolic syndrome. Determination of AST/ALT ratio could thus help to predict the development of NAFLD in individuals with metabolic syndrome.
Authors and Affiliations
P. Deepa, N. Sasivathanam
Keywords
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