A Study of Bacteriological Profile and Their Sensitivity Pattern in Neonatal Sepsis at Tertiary Care Hospital in Mysore, Southern India
Journal Title: Scholars Journal of Applied Medical Sciences - Year 2015, Vol 3, Issue 7
Abstract
Epidemiology and surveillance of neonatal sepsis helps in implementation of rational empirical antibiotic strategy. 60 consecutive babies over 1year period with suspected sepsis based on risk factors and clinical presentation were included in this study. All the babies underwent blood culture. Blood culture sample included a single sample from peripheral vein or artery. Blood culture report and sensitivity pattern was noted. In total, 80% (48 of 60) of the clinically suspected cases were culture-proven cases of neonatal sepsis, which isolated 9 pathogens. Gram negative organisms were isolated from 31 (64.5%). Klebsiella pneumoniae (19 out of 48, 40%) was the most common gram negative organism and most common causative agent of neonatal sepsis. Gram positive organisms were isolated from 15 (31.2%). Coagulase-negative staphylococci 10 (20.8%) were the most common gram-positive agent. The 19 Klebsiella pneumoniae isolates were 100% susceptible to Amikacin, Ciprofloxacin, Ofloxacin and Meropenem; and 100% resistant to Amoxyclav, ampicillin, Ceftazidime and Cefotaxime. Other Gram negative organisms isolated (Pseudomonas, E.coli, and Acinetobacter) were 100% sensitive to Amikacin, Ciprofloxacin, Levofloxacin, Piperacillin Tazobactum and Meropenem. E.coli was totally sensitive for Ceftriaxone, Ceftazidime, and Cefotaxime. All isolated E.coli were resistant to Amoxyclav and Ampicillin. All the gram positive isolates were 100% susceptible for Linezolid and Vancomycin. Bacteriological profile in neonatal sepsis in our locality is dominated by Gram negative bacteria, Klebsiella pneumoniae. Second commonest bacteria isolated are Staphylococcus, with 61.5% being Coagulase Negative strain. Ciprofloxacin and Amikacin would be appropriate as empirical first line antibiotic for suspected neonatal sepsis in our locality. Keywords: Bacteriological profile, Neonatal sepsis, Blood culture, Antibiotic sensitivity, Gram negative organisms, Gram positive organism.
Authors and Affiliations
Dr. Vinay BS, Dr Kruthi BN, Dr. Girish GN
Keywords
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