A Study of Cardiac Parameters using Impedance Plethysmography (IPG) in Healthy Volunteers
Journal Title: Journal of Physiology and Pharmacology Advances - Year 2012, Vol 2, Issue 11
Abstract
Impedance plethysmography is non – invasive technique to measure blood flow in any part of the body like heart (Impedance Cardiography), arteries or veins. As only heart rate and blood pressure is not sufficient to access a person‟s hemodynamic status, cardiac output and other cardiac parameters measured by this simple technique will help further to access heart‟s functional status with avoidance of all complications associated with previous catheter related invasive techniques. Main aim of the study was to measure cardiac parameters noninvasively in healthy volunteers of all age groups of both sex using impedance cardiography and then compare them between different age groups. Study was done in 5 age groups (16 – 25 yrs, 26 – 35 yrs, 36 – 45 yrs, 46 – 55 yrs and > 55 yrs) and in total 400 subjects. Each group was of 80 healthy volunteers of either sex. It was carried out on Nivomon Series computerized software in Bhavnagar region. Cardiac parameters measured were SV – Stroke Volume, SI - Stroke Volume Index, CO – Cardiac Output, CI – Cardiac Index, LVET – Left Ventricular Ejection Time, SVR – Systemic Vascular Resistance and SVRI - Systemic Vascular Resistance Index. Normative baseline laboratory data obtained from 400 healthy volunteers were as: SV - 65.15 ± 13.18 ml / beat, SI - 38.16 ± 7.64 ml / beat / m², CO - 4.94 ± 1.09 lit. / min, CI - 2.91 ± 0.51 lit. / min / m², LVET - 357.35 ± 46.32 msecs, SVR - 1500.95 ± 305.45 dyne•sec / cm5 and SVRI - 2507.75 ± 441.63 dyne•sec / cm5 / m². These values were found to be consistent with normal reference range. So now these baseline normative data will be helpful in many future research studies related to heart function in Bhavnagar region for this novel instrument. Significant differences were found for all parameters between different age groups. LVET and SVR were found on higher side in later ages due to atherosclerosis and other age related changes. Positive correlation was found between BSA and SV, CO. Negative was the case for BSA and SVR. In case of gender difference in last age group, Zo was found to be extremely higher in females due to higher fat proportion. Also SV was significantly lower and SVR was higher in females but no difference was there for CO and LVET. Overall, cardiac parameters were measured with this impedance technique accurately. Although there were some limitations, this technique was found to be simple, cheap and effective. If this technique is further validated and established, than it can be used widely for many physiological and pharmacological studies on human heart. Further, it can be used in ICU, in clinical set up for many heart disease patients, and also in CCU or in emergency trauma centres for other critically ill patients.
Authors and Affiliations
C. V. Parmar , D. L. Prajapati , V. V. Chavda , P. A. Gokhale , H. B. Mehta , C. J. Shah
Keywords
Related Articles
- EP ID EP141308
- DOI -
- Views 104
- Downloads 0
Plasma Total Protein, Serum Calcium and Inorganic Phosphate Levels in Nigerian Horses with Natural Piroplasmosis
The objectives of this study were to determine alterations in plasma total protein, serum calcium and phosphorus levels in horses with natural piroplasmosis. Knowledge of these alterations, enable clinicians decide on th...
Fermentation of Cocoa Beans and Antimicrobial Potentials of the pod Husk Phytochemicals
The disc diffusion method was used in determining the antibacterial efficacy of methanol extract of cocoa pod husk, (CPH). Fermentation and proximate analysis of cocoa beans were carried out. Distinct increase in the bac...
Experimental In Vitro Mouse and Human Stem Cell Models for Balanced Activity of Oncogenes and Tumor-Suppressor Genes
Taking in consideration many literature data, according which coordinated oncogenes and tumor-suppressor genes functions is of most importance. In this connection, the main idea was balanced activity of oncogenes and tum...
The Hot Water Extract of Angelica Gigas Nakai Root Promotes Adipogenic Differentiation via Activation of the Insulin Signaling Pathway in 3T3-L1 Cells
In this study, the effects of the hot water root extract of Angelica gigas Nakai (AGN) on the differentiation of 3T3-L1 preadipocytes and the possible mechanism of glucose transport were investigated. Post-confluent 3T3-...
Vasoactive Properties of an Extract of Allium Sativum in the Rat Aorta
The aim of this study was to determine whether an hydro-alcoolic extract of cloves of Allium sativum is able to induce a relaxant effect in the rat aorta and so the mechanism underlying this effect. Rat aortic rings were...