A Study of Clinical, Hematological and Etiological Profile of Pancytopeniaat a Tertiary Care Center in Andhra Pradesh, India.
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2019, Vol 18, Issue 3
Abstract
Background: Pancytopenia is a triad of anemia, leucopenia and thrombocytopenia. The initial symptom would be generalized weakness. Etiology ranges from benign to malignant conditions. Accurate workup is essential for the appropriate management. Aim: To studythe clinical presentation, bone marrow picture andthe causes of pancytopenia. Materials and methods: This study is carried out in Government General Hospital, Kakinada which is a tertiary care center. All the patients with pancytopenia admitted in the Department of General Medicine were considered in the present study. 50 cases presented with pancytopenia were analyzed. The clinical findings, blood investigations and bone marrow examination findings were recorded.The various causes of pancytopenia were tabulated and analyzed. Results: The commonest symptom present in all cases was generalized weakness (100%) followed by fever (42%). Pallor was the most common clinical feature seen in all 50 cases (100%). Splenomegaly was seen in 36% of cases, hepatomegaly in 24%, jaundice in 8%,bony tenderness in 4% and lymphadenopathy in 6%. The commonest cause of pancytopenia was megaloblastic anemia due to vitamin B12 deficiency seen in 40% of cases, followed by aplastic anemia seen in 28% of cases. Conclusion: Pancytopenia is a common hematological entity encountered in routine clinical practice and accurate subclassification is needed. When detected early, good therapeutic response can be achieved.
Authors and Affiliations
Dr. Sriramaneni Nikitha, Dr. P. Satish Srinivas, Dr. M. V. V. Tirumala Rao
Keywords
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- EP ID EP555213
- DOI 10.9790/0853-1803072731.
- Views 54
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