A study of cutaneous adverse drug eruptions in dermatologic practice
Journal Title: IP Indian Journal of Clinical and Experimental Dermatology - Year 2016, Vol 2, Issue 3
Abstract
Cutaneous adverse drug reactions (CADR) are a major problem in drug therapy and is one of the leading causes of morbidity and mortality in health care. Objectives: 1) To study the diverse clinical spectrum of CADR. 2) To assess the causality and identify the offending drug. Materials and Methods: Present study was an 18 months prospective, hospital based study conducted, recording a total of 100 patients with various cutaneous ADR. The diagnosis of cutaneous drug reactions was made mainly based on detail history and correlation between the intake of probable offending drug and the onset of rash. Results: The most common type of CADR patterns recorded among the 100 cases in the present study were Maculopapular rash (30%), Fixed drug eruption & bullous variant (19%), Acute urticaria (18%), Acneiform eruptions (6%), Erythema multiforme & Stevens – Johnson syndrome (SJS) in (5%), Exfoliative dermatitis & Photosenstivity in (4%), Angioedema, Vasculitis & Hyperpigmentation in (2%), Toxic epidermal necrolysis (TEN), Drug hypersensitivity syndrome & Pruritus in (1%) each. The drugs most often implicated were Antimicrobials(40%), NSAIDs (30%), and Anticonvulsants (11%). Antimicrobials were implicated in (43.3%) of Maculopapular rash followed by NSAIDs (33.3%). Antimicrobials (52.6%) and NSAIDs (42.1%) in FDE. Urticarial reaction was caused mainly by NSAIDs (44.3%). Life threatening severe cutaneous adverse drug reactions (SCARs) such as SJS, TEN & Drug hypersensitivity syndrome (DHS) were seen 7% of total cases. Conclusion: Although it was a monocentric study, this study revealed a high frequency of cutaneous drug reactions with different clinical presentations, induced by frequently used antibiotics, analgesics and anticonvulsants as and when used giving an interesting data with respect to onset, severity and clinical presentation.
Authors and Affiliations
Sai Kranthi Kumar Varma Nadimpalli, Purnachandra Badabagni, Subbarao Dasika, Ramachandra Bendapudi V
Keywords
Related Articles
- EP ID EP243500
- DOI -
- Views 133
- Downloads 0
A prospective study of correlation between hormonal profile and acne vulgaris in adult patients
Introduction Although various studies has been conducted regarding pathogenesis of acne vulgaris and proved it to be multi factorial but there is strong association between acne vulgaris and hormone profile of patients P...
Primary Systemic Amyloidosis – A Great Mimicker
A 40 year old female patient presented with myalgia and both knee joint pain for 3 years and raised skin lesions over both eyelids for 1 year. General examination and systemic examination were normal and vitals were stab...
A study of dermatological manifestation of viral exanthems in a tertiary care center
Introduction Viral fevers are now a days common in and around the spring season They involve all system of the body including skin We tried to review possible dermatological manifestation of all suspected and diagnosed c...
Dermatologist in the era of social media: challenges and solutions
Dermatologist in the era of social media: challenges and solutions
The incidence of vitiligo and its clinical features in response to Psoralen group of drugs and associated other diseases
Background: Vitiligo incidence and treatment modalities are diverse and remain unsatisfactory. There is high incidence of vitiligo among patients suffering from systemic disorders. Aim: The present study was undertaken t...