A study of effectiveness of statins in patients of rheumatoid arthritis at tertiary health care centre
Journal Title: Medpulse International Journal of Pharmacology - Year 2019, Vol 10, Issue 3
Abstract
Background:Rheumatoid arthritis is chronic inflammatory condition involving multiple systems. Statims have anti-inflammatory properties like regulating leukocyte-endothelial cell adhesion, reducing nitric oxide (NO) production and decreasing levels ofTNF-alpha, IL-1 and IL-6.Aim and objective:to study the effectiveness of statins in patients of rheumatoid arthritis.Methodology:Present study was conducted in 76 patients diagnosed as rheumatoid arthritis.Study population were divided into two groups. Group A included patients receiving DMARD therapy with statins. Group B included patients only receiving DMARD therapy.Clinical examination was done. Clinical outcome variable of RA DAS28 was noted. Patients of both groups were followed up after 6 months of initial observation. Both the clinical and biochemical variables were also noted during follow-up visits.After follow up both the groups were compared for biochemical parameters like ESR, CRP and clinical parameters.Results:In our study both the groups were comparable in age, gender, ESR, CRP and DSA28 . (p value >0.05).statistically significant difference was found in ESR, CRP, Total cholesterol , serum HD and DSA28 of both the groups(p >0.05)
Authors and Affiliations
Syeda Ayesha Fatima, Swetha G, Neeraj Sadiq, Ahmed Abdul Bari Hazari
Keywords
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