A STUDY OF EFFECTS OF ORAL CLONIDINE ON PREMEDICATION AND HAEMODYNAMIC CHANGES DURING LAPAROSCOPIC SURGERY
Journal Title: Journal of Evidence Based Medicine and Healthcare - Year 2016, Vol 3, Issue 14
Abstract
BACKGROUND Use of Clonidine as a premedicant started incidentally. Clonidine is a potent antihypertensive drug that suppresses RAAS. Clonidine may be beneficial during laparoscopy in patients with hypertension, cardiovascular and/or renal diseases. AIM OF STUDY To determine the effects of Oral Clonidine on premedication and haemodynamic changes during Laparoscopic surgery. MATERIAL AND METHODS Study was conducted on 60 adult patients belonging to ASA physical status I & II. They were randomly assigned to 2 groups of 30 each. Group C received oral clonidine 150 mcg 90 minutes before surgery and group P received oral ranitidine 150 mg 90 minutes before surgery. Sedation score was noted on arrival to operation theatre. All vital parameters were recorded at regular intervals intra-operatively. RESULTS Clonidine premedication was able to achieve haemodynamic stability during pneumoperitoneum. CONCLUSION Premedication with 150mcg oral Clonidine has been found to be relatively safe as well as effective method that provides stable haemodynamics and protection against stress response triggered by pneumoperitoneum in patients undergoing laparoscopic surgeries.
Authors and Affiliations
Sanjeev Rao A, Mahesh M
Keywords
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- EP ID EP232696
- DOI 10.18410/jebmh/2016/111
- Views 60
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