A Study of Efficacy and Safety of Betadine Pleurodesis.
Journal Title: International Journal of Medical Science and Innovative Research (IJMSIR) - Year 2017, Vol 2, Issue 6
Abstract
Background: Pleurodesis is a procedure to achieve symphysis between the two layers of pleura aimed at preventing accumulation of either air or fluid in the pleural space. The most common indication is malignant pleural effusion. A plethora of chemical agents have been used for pleurodesis and iodopovidone (Betadine) is one such agents. This study was undertaken to evaluate the efficacy and safety of Betadine (lodopovidone) as an agent for chemical pleurodesis. Methods: It is a prospective clinical study conducted at Government Hospital for Chest and Communicable Diseases (GHCCD), Visakhapatnam. A total of 44 patients were included. All the patients had either malignant pleural effusion or spontaneous pneumothorax. After the Inter Costal Tube drainage (ICTD) each patient underwent pleurodesis with 10% Betadine at varying times. The patients were then followed up as an outpatient for 3 months. During the follow up, all the patients were assessed by chest X-ray (CXR) at 1 week, 1 month and 3 months. The radiological resolution and the subjective response of the patients were assessed. Results: 44 patients were analyzed (14 females, 30 males). 64% of the cases were malignant pleural effusion and 36% were cases of spontaneous pneumothorax. Post Betadine pleurodesis, 29 (66%) patients complained of mild pain followed by dyspnea 8 (18%) and low grade fever 6 (14%). Recurrence was observed in 3(11.6%) patients at 3rd month visit and in 1(3.8%) patient at 1st month visit in Malignant Pleural Effusion (MPE) group. Recurrence was observed in 1(6. 25%) patient in pneumothorax (PNTX) group at 3rd month visit. 22(84. 6%) patients of MPE group and 15(93.75%) patients of pneumothorax group achieved successful pleurodesis. Failure of the pleurodesis procedure was observed in 4(15.4%) patients of MPE group and 1 (6.25%) patient of pneumothorax group. Conclusion: From this study, it can be concluded that in resource constrained setups, Betadine is a reasonable choice for chemical pleurodesis.
Authors and Affiliations
Dr. M. V. Shanti Annapurna
Keywords
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