A STUDY OF EFFICACY OF LURASIDONE IN PATIENTS SUFFERING FROM SCHIZOPHRENIA AND RELATED DISORDERS
Journal Title: Journal of Advanced Medical and Dental Sciences Research - Year 2017, Vol 5, Issue 3
Abstract
Background: Persistent symptoms, or experience side effects are associated with many outpatients with schizophrenia or schizoaffective disorder, associated with their current maintenance antipsychotic. Treatment strategies include dose adjustments, addition of adjunctive medications, or allowing the passage of time in the hopes of achieving further symptom reduction and the diminution of adverse effects. Hence; we planned the present study to assess the efficacy of Lurasidone in Patients Suffering from Schizophrenia and Related Disorders. Materials & methods: 30 adult patients diagnosed as suffering from schizophrenia and related disorders (Psychosis NOS) according to DSM 5 were administered Tablet Lurasidone - a new atypical anti-psychotic medicine. The patients were evaluated at day 0, 20, 50 and 80 days of the Study in an open clinical trial. The efficacy and side effects of drugs were assessed with the help of Brief Psychiatric Rating Scale, The Schizophrenia Cognition Rating Scale, Clinical Global Impression Scale, Dosage and Treatment Emergent Scale and Abnormal Involuntary Movement Scale. Laboratory investigations were also done in each patient before and after the study. The dosage ranged from 40 mg – 80 mg daily, the majority being on 80mg/day. All the results were compiled and analyzed by SPSS software. Results: There was statistically significant clinical improvement measured on Severity of Illness sub-scale, at day 20, 50 and 80 in comparison with that at day 0. The same was true for Brief Psychiatric Rating Scale and its three sub-scales- The Depression Sub-Scale, Thinking Disorder Sub-scale and Anergia Sub-Scale. 2 patients didn't complete the study. There was significant improvement on Schizophrenia Cognition Rating Scale on day 20, 50 and 80 in comparison to day 0. Akathesia was the main side effect requiring reduction of dosage or switch to another anti- psychotic. None of the patients showed any abnormal involuntary movements. Conclusion: Lurasidone is an effective and useful drug for the treatment of schizophrenia and related disorders.
Authors and Affiliations
V. P. Mahla, Abhishek Kapoor, Avisha Mahla, Rahul Rai
Keywords
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