A STUDY OF EPICARDIAL ADIPOSE TISSUE (EAT) AND CAROTID INTIMA-MEDIA THICKNESS (CIMT) IN PATIENTS WITH AND WITHOUT ISCHAEMIC HEART DISEASE
Journal Title: Journal of Evolution of Medical and Dental Sciences - Year 2017, Vol 6, Issue 81
Abstract
BACKGROUND Early diagnosis can be an important measure to reduce the CAD-related morbidity and mortality. Carotid intima-media thickness (CIMT) is one such measure which has been validated as a surrogate marker for subclinical atherosclerosis and is used for early detection of accelerated disease process and subclinical disease. Over the past decade, epicardial fat thickness has generated interest as a marker for atherosclerosis, after being found to have a strong association with visceral obesity. At the same time, other studies have questioned the association. There is paucity of data for epicardial fat thickness as a marker for atherosclerosis in Indian population. This study tries to explore the relationship between coronary artery disease and the two markers of atherosclerosis- Carotid intima-media thickness and Epicardial Fat. MATERIAL AND METHODS 500 study subjects each, were enrolled under two groups of cases and controls, after coronary angiogram, depending on presence of either normal epicardial coronaries (no CAD- Group 1) which was the control group or significant CAD (Group 2) which was the case group. EAT (Epicardial Adipose Tissue) thickness and CIMT were measured. RESULTS Group 1 subjects (no CAD) had a median age of 52.84 ± 9.39 years, with 62.4% males, and Group 2 (CAD) had a median age of 55.22 ± 9.16 years with 84% males. On multiple regression analysis, male sex, age, total cholesterol, HDL, LDL, waist circumference and hip circumference were found to be significant predictors of CAD. Mean epicardial fat thickness differed significantly between the two groups (p<0.001), whereas the difference in CIMT between the two groups was not statistically significant. On comparison of EAT thickness quartiles with Gensini score, EAT thickness did not increase with increasing severity of CAD. CONCLUSION Our study shows that increased EAT thickness is associated with significant epicardial obstructive CAD. Epicardial fat thickness, but not CIMT, can differentiate patients with CAD among a population of patients with coronary risk factors and suspected CAD. Epicardial fat thickness did not increase with increasing severity of CAD.
Authors and Affiliations
Jayaram Vasu, Cicy Bastian, Deepak Garg
Keywords
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- EP ID EP275493
- DOI 10.14260/jemds/2017/1241
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