CHANGING PATTERN OF CUTANEOUS ADVERSE DRUG REACTION
Journal Title: Journal of Evolution of Medical and Dental Sciences - Year 2018, Vol 7, Issue 23
Abstract
BACKGROUND Adverse drug reactions (ADRs) are unwanted or unintended effects of drugs, which occur during proper use of a drug. The pattern of cutaneous adverse drug eruptions and the drugs responsible for them had shown more or less similar pattern in various studies. The objective of our study was to ascertain the changing pattern of clinical spectrum of ACDRs, the causative drugs and to find current trend in a tertiary care centre. MATERIALS AND METHODS All patients who attended the dermatology OPD/IPD of the hospital from 28-02-2016 to 20-05-2017 were screened. Suspected cases of ADRs were independently assessed by dermatology consultant of the department and subsequently causality assessment was done by causality assessment committee using WHO-UMC causality assessment scale. Only those cases where the causality was certain, probable/ likely or possible were recorded. RESULTS In the present study, total number of subjects was 98. Most common culprit drugs were antibiotics (47), in which fluoroquinolones + nitroimidazole (30) were most common causative agent. Fixed Drug Eruption (FDE) was the most common cutaneous ADR reported in our study. It occurred in 46.94% of patients. Morbilliform drug rash was the second most common cutaneous adverse drug reaction in 28.57% of patients. CONCLUSION From current study, it is concluded that FDE is becoming most prevalent type of cutaneous ADR than Morbilliform drug rash. Commonest culprit drug now are fluoroquinolones + Nitroimidazole combination followed by NSAIDs and Cephalosporins. Cutaneous ADRs are now less reported with sulphonamide, which were the most common culprit drug reported in previous studies.
Authors and Affiliations
Sadhna Kaushik, Neeraj Srivastava, Vinay Kumar
Keywords
Related Articles
- EP ID EP439374
- DOI 10.14260/jemds/2018/630
- Views 63
- Downloads 0
COLORECTAL NEOPLASMS- A STUDY OF CLINICO-MORPHOLOGICAL PATTERNS AND THEIR PROGNOSTIC VALUE IN A TERTIARY CARE CENTRE
BACKGROUND Colorectal cancer is a formidable health problem, being second most prevalent neoplasm worldwide with 2.4 million people living with it. Incidence of CRC is higher in males (sex ratio M: F= 1.4/1) and mean age...
FACTORS AFFECTING THE NUTRITIONAL STATUS OF 3-6-YEAR-OLD CHILDREN ATTENDING ANGANWADIS IN AN URBAN AREA IN KERALA
BACKGROUND Although, Kerala is far ahead of other states of India with regard to most of the health indicators under nutrition is still present here. This is especially true in some urban areas, where the health delivery...
LONGSTANDING DERMATOFIBROSARCOMA PROTUBERANS- A CASE REPORT
PRESENTATION OF CASE A 42-year-old male presented to surgical OPD with a slow growing painless swelling in the left inguinal region since 3 years. He did not have history of similar swellings anywhere in the body. He did...
EFFECT OF KAPALBHATI PRANAYAMA ON WAIST AND HIP CIRCUMFERENCE
[b]CONTEXT (BACKGROUND) AND AIMS[/b]: Rapid industrialization, environmental pollution, overcrowding, sedentary lifestyle and various stress factors are responsible for the deterioration of the physical health...
DEXMEDETOMIDINE: AN IDEAL DRUG FOR PROCEDURAL SEDATION OUTSIDE OPERATION THEATRE
Procedural sedation and analgesia (PSA) is a method of administering sedatives or dissociative agents to patients undergoing unpleasant procedures. It has become the international standard of care for managing...