COLORECTAL NEOPLASMS- A STUDY OF CLINICO-MORPHOLOGICAL PATTERNS AND THEIR PROGNOSTIC VALUE IN A TERTIARY CARE CENTRE
Journal Title: Journal of Evolution of Medical and Dental Sciences - Year 2018, Vol 7, Issue 10
Abstract
BACKGROUND Colorectal cancer is a formidable health problem, being second most prevalent neoplasm worldwide with 2.4 million people living with it. Incidence of CRC is higher in males (sex ratio M: F= 1.4/1) and mean age of presentation being 62 yrs. As per Cancer registry, Bhopal, there are 40 - 60 cases of colorectal cancer per year with mean age of presentation being 53.27 ± 15.9 and M: F ratio of 1.5: 1. We aimed at studying histomorphological features of CRC cases and correlating it with several clinical aspects to explore their role in patient’s prognosis in our institute. MATERIALS AND METHODS The descriptive study encompassed 50 surgically resected primary CRC specimens and biopsies received during five years period. Tissue samples were processed and unstained (3-μm) sections from formalin-fixed paraffin-embedded tumours were subjected to H and E staining. We excluded cases with benign lesions, previous use of anti-neoplastic, chemo or radiotherapy and associated with other concomitant malignant pathological conditions. The study variables were analysed by chi-square test, Z tests and student ‘t’ test. RESULTS Mean age of presentation was 51.98 yrs.; M: F ratio was 0.9: 1 with greater predilection for lower socioeconomic status. Nonvegetarians were more commonly associated with PDAC. In our study, left-sided colon cancers and rectum cancers outnumbered right-sided cancers. Right-sided tumours mainly presented with pain abdomen, weakness and fatigue, whereas pain and per rectal bleeding being the commonest symptoms in left-sided CRCs. Majority were left-sided lesions that showed ulcerative growth patterns and were poorly differentiated (p value= 0.042) and carried poor prognosis. Majority belonged to Dukes Stage A and B (70%), TNM Stage: T2N0M0 (45%), AJCC Stage II (50%) and Astler and Coller classification Stage B2. Tumours with higher histological grading, later stages and poor differentiation carried poor prognosis. CONCLUSION Since correct histopathological diagnosis is directly related to prognosis, hence proper analysis of spectrum of CRC with clinicopathological correlation is the boon for good assessment of cases.
Authors and Affiliations
Niharika Singh, Puneet Tandon
Keywords
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- EP ID EP411305
- DOI 10.14260/jemds/2018/278
- Views 87
- Downloads 0
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