A Study of Free radical activity in thalassaemia major patients in South Bengal
Journal Title: Journal of Medical Science And clinical Research - Year 2015, Vol 3, Issue 9
Abstract
Thalassaemias are commonest single gene disorder, the production of normal heamoglobin is partly or completely suppressed due to defective synthesis of one or more globin chains. Loss of AHSP, precipitation free α-Hb iron that generate ROS thereby causing peroxidative RBC membrane and tissue damage leding to Increased MDA(Malondialdehyde) & RBC SOD levels . Two hundred and fifty one diagnosed thalassaemic subjects from 6months-40 years of age attending thalassaemia care centres in Burdwan were investigated for Plasma MDA /SOD and RBC SOD. The control group shows SOD levels 5.98±1.72U/ml (RBC) 3.79±1.42 U/ml (Plasma) & Plasma MDA 6.86±1.72 nmol/ml. In beta Thal patients RBC-SOD was 13.76±2.22 U/ l and Plasma-SOD 08.100±1.88 U/ l, Plasma MDA 15.12±2.28 nmol/ml was observed. Conclusion: Plasma SOD & MDA in thalassaemia major patients is raised due to generation of production of Reactive Oxygen Species (ROS) as a consequence to formation of hemichromes heamolysis of Red Blood Cells and Iron overload.
Authors and Affiliations
Prof Tamal Kanti Ghosh
Keywords
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