A Study of Glucosylceramide Synthase and Glycolytic Pathway Enzymes in Patients with Hypereosinophilia
Journal Title: International Journal of Immunotherapy and Cancer Research - Year 2017, Vol 3, Issue 1
Abstract
Glucosylceramide synthase is the rate limiting enzyme in ceramide glycosylation and shifts the balance between ceramide and glycosphingolipids towards proliferation and survival of cancer cells. Increased glucose availability and glycolytic metabolism is preferentially used by cancer cells and has been linked to glycosphingolipid formation. We measured gene expression levels of glucosylceramide synthase and of glycolytic pathway enzymes, glucose transporter 1 and hexokinase II, as well as protein expression of glucosylceramide synthase, on trephine biopsy samples from 13 patients with hypereosinophilia, We found no significant differences in expression levels of any of the enzymes in patients with secondary causes of hypereosinophilia compared to those with either suspected or proven clonal hypereosinophilia.
Authors and Affiliations
Redmond Lisa, Kennedy Paul, Buckley Colm, Murphy Philip T
Keywords
Related Articles
- EP ID EP348807
- DOI 10.17352/2455-8591.000014
- Views 115
- Downloads 0
Significance of Cancer Stem Cells in Anti-Cancer Therapies
Stem cells are the focus of cutting edge research interest because of their competence both to self-renew and proliferate, and to differentiate into a variety of tissues, offering enticing prospects of growing replacemen...
Analysis of Risk Factors for Development of Hepatocellular Carcinoma in Chronic HBV - Infected Liver Cirrhosis Patients: A Meta-Analysis
The 5-year cumulative incidence rate of hepatocellular carcinoma (HCC) in chronic HBV -infected liver cirrhosis (LC) patients was up to 5%-30%. However, existing medical interventions can’t cure chronic HBV -infected LC...
A Study of Glucosylceramide Synthase and Glycolytic Pathway Enzymes in Patients with Hypereosinophilia
Glucosylceramide synthase is the rate limiting enzyme in ceramide glycosylation and shifts the balance between ceramide and glycosphingolipids towards proliferation and survival of cancer cells. Increased glucose availab...
Adiponectin Regulates the Development and Progression of MCA-Induced Sarcoma in Mice
Background: Sarcomas are malignant tumors with low survival rates and remain refractory to the current therapeutic methods. Adiponectin plays crucial roles in many physiological responses. Studies have shown that adipone...
SMART Drug Based Targeted Delivery: A New Paradigm for Nanomedicine Strategies
Introduction: Targeted drug delivery systems are nanoscale drug carrier molecules designed for improving the communication of cellular and molecular components and biodistribution of tumour targeted drug (chemo) therapeu...