Significance of Cancer Stem Cells in Anti-Cancer Therapies
Journal Title: International Journal of Immunotherapy and Cancer Research - Year 2016, Vol 2, Issue 1
Abstract
Stem cells are the focus of cutting edge research interest because of their competence both to self-renew and proliferate, and to differentiate into a variety of tissues, offering enticing prospects of growing replacement organs in vitro, among other possible therapeutic implications. It is conceivable that cancer stem cells share a number of biological hallmarks that are different from their normal-tissue counterparts and that these might be taken advantage of for therapeutic benefits. In this review we discuss the significance of cancer stem cells in diagnosis and prognosis of cancer as well as in the development of new strategies for anti-cancer drug design.
Authors and Affiliations
qBotelho Mónica, Alves Helena
A Very Rare Case of Polycythemia Vera Patient Who Developed Other Four Cancers
We find more and more often patients with two or more synchronous or metachronous cancers, who raise various issues on the risk factors and pathways. A polycythemia vera male patient, diagnosed at 44 years, evolved towar...
Are Cladribine and Rituximab Enough for the Treatment of Relapsed Hairy Cell Leukemia?
Introduction: Hairy cell leukemia is a rare B-cell lymph proliferation with long-term survivals, in general. Although therapeutic possibilities have progressed over time, many patients have recurrences and the disease ca...
A Study of Glucosylceramide Synthase and Glycolytic Pathway Enzymes in Patients with Hypereosinophilia
Glucosylceramide synthase is the rate limiting enzyme in ceramide glycosylation and shifts the balance between ceramide and glycosphingolipids towards proliferation and survival of cancer cells. Increased glucose availab...
N-Methyl-D-Aspartate (NMDA) Receptors: Therapeutic Target against Cancer
Glutamate (Glu) mainly acts as an excitatory neurotransmitter in the central nervous system controlling variety of neuro-physiological functions like synaptic signaling, learning, memory, etc. However, uncontrolled or ex...
Adiponectin Regulates the Development and Progression of MCA-Induced Sarcoma in Mice
Background: Sarcomas are malignant tumors with low survival rates and remain refractory to the current therapeutic methods. Adiponectin plays crucial roles in many physiological responses. Studies have shown that adipone...