“A Study of Hyperthyroidism in Pregnancy”
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2017, Vol 16, Issue 12
Abstract
Background: Overt hyperthyroidism constitutes special risk to the mother including precipitation of hypertension, CCF & pre-eclampsia as well as higher rate of miscarriage, pre-term delivery & placental abruption. It can lead to neonatal & foetal hyperthyroidism with risk of IUGR & stillbirth. Objectives: This study was conducted to study various clinical & laboratory profile of pregnant patients with hyperthyroidism along with correlation of maternal & foetal outcome. Methods: This article reviews our experience with 40 hyperthyroid pregnant patients (IPD & OPD) who were included in the study after screening them on their first visit and after valid written informed consent. Patient’s demographic data; symptoms; past medical & obstetric history; diet & drug intake; comorbid conditions; clinical, local (including thyroid enlargement & eyes) & systemic examination findings; routine & special investigation findings; maternal complications and both maternal & foetal outcome were all documented on case record form. Chi-square (Pearson’s) and Fischer exact test were used to calculate the statistical significance and a P value of 0.05 or less for Chi-square test & 0.20 or less for Fisher exact test considered statistically significant. Results: Commonest symptom was palpitation (45%) and commonest sign was tachycardia (82.5%); Goitre was present in 11 cases (27.5%); Redness of eye (25%) was most common eye signs; Anaemia was detected in 50% of cases along with hypocalcaemia (95%). Majority (97.5%) of patient had serum Anti-TPO antibody positivity with 60% patients having overt hyperthyroidism. Maternal outcome was better with only 7.5% cases had first trimester abortion whereas 16.67% foetuses were LBW & 2.78% had hypothyroidism. Conclusion: Universal screening for hyperthyroidism should be done in all age group of pregnant patients with special attention to older women to improve maternal & foetal outcome. With adequate treatment and regular follow up, morbidity and mortality due to hyperthyroidism in pregnancy can be prevented.
Authors and Affiliations
Vikrant Bhagat, Dhirendra Yadav, Sameer Yadav, N D Moulick
Keywords
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- EP ID EP250799
- DOI 10.9790/0853-1612065563
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