A Study of Paclitaxel Induced Acute Pain Syndrome: A Prospective Study done at State Cancer Institute J&K
Journal Title: Journal of Medical Science And clinical Research - Year 2018, Vol 6, Issue 9
Abstract
Objectives: To describe the incidence and characteristics of paclitaxel induced acute pain syndrome and asses the change in pain related to paclitaxel dose and number of cycle. Methods: The Study was prospective in which we included the eligible patients scheduled to receive paclitaxel weekly or 3 weekly; alone or in combination with another chemotherapeutic agent Carboplatin. Details regarding acute Pain were collected and evaluated. Results: Majority of patient who developed P-APS, received combination of chemotherapy as compared to patients who received chemoradiation or paclitaxel alone. The P-APS was measured on the basis of scoring provided by LANSS pain scale, majority of patients had pain score of less than 12. As far as nature of pain was concerned, we found that the commonest complaints were pinpricking (34.29%) and dull (22.8%) rather than burning (14%), numbness experienced in the knees(44%) followed by in lower limbs (24%), hand (15%), feet(8%), and 4% in ankle. Conclusion: The incidence and characteristics of pain is related to paclitaxel dose and number of cycles. Subsequent cycles of paclitaxel are having no effect on intensity of pain syndrome. Duration of pain increases if patients receive combination of Paclitaxel and carboplatin. Addition of radiation is having neither synergistic nor protective effect in our study.
Authors and Affiliations
Dar Abdul Waheed
Keywords
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