A study of post-operative pain and sedation in response to low dose dexmedetomidine infusion in patients undergone laparoscopic surgery
Journal Title: Medpulse International Journal of Anesthesiology - Year 2017, Vol 2, Issue 2
Abstract
Background: The laparoscopic surgeries allow significant reduction in post-operative pain, there may be pain resulting from the diaphragmatic irritation. Multimodal analgesia is now recommended to prevent and treat the post-laparoscopic pain. Aims and Objective: To study the effect of low dose dexmedetomidine infusion on post-operative pain and sedation in the patients undergone laparoscopic surgery. Materials and Method: In the present study we selected total 60 patients aged 20-60 years of either sex admitted for laparoscopic surgery under general anesthesia with ASA physical grade I or II. All the selected patients were randomly allocated in three groups containing 20 patients each. Control group in which patients received normal saline 0.9% infusion during the procedure. In Group A the patients received dexmeditomidine infusion 0.2 mcg/kg/hr and in Group B the patients received dexmeditomidine infusion 0.4 mcg/kg/hr. The base line parameters of the patients including heart rate (HR), pulse oximetry (SPO2), Noninvasive Systolic blood pressure (SBP), Diastolic Blood pressure (DBP), Mean Arterial pressure (MAP) and End tidal Co2 (Etco2) were measured intra operatively and post operatively also. Post operative pain score was calculated by using visual analog scale. It was calculated 2, 4, 8, 16 and 24 hrs post operatively. The post operative sedation was calculated by using Ramsay sedation score. The mean duration of surgery was 92.71 ± 14.19 in control group while in group A and group B was 88.72 ± 17.82 and 88.34 ± 16.65min respectively. The difference observed between mean duration of surgery and man duration of infusion between control group with group A and B was statistically insignificant. Results: The pain score was 7.07±1.51 in control group and 7.07±1.51 and 7.07±1.51 in group A and B. The pain score was decreasing with time more in group A and B as compared to control group. The difference observed in pain score in control group with group A and B was statistically significant. It was observed that the sedation score immediately after surgery were statistically significant in group A and B as compared to control group. After 24 hours the sedation score was nearly same all the three groups and the difference was not statistically significant. Conclusion: Dexmedetomidine decreased the post-operative pain level and has produced better sedation scores as compared with control group.
Authors and Affiliations
Abhinay Ramchandra Harankhedkar, Prakash Kisanrao Surwade
Keywords
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