A study of role of allopurinol in prevention of ischemic myocardial injury in rabbits
Journal Title: International Journal of Research in Pharmacology & Pharmacotherapeutics (IJRPP) - Year 2017, Vol 6, Issue 4
Abstract
The pathogenic process following ischemia of heart and brain is responsible a toll of deaths world over. The radicals like superoxide, hydroxyl radical, alkoxy or lipoxy radical can induce a huge damage over cardiovascular system. Xanthine oxidase mediated production of superoxide radicals has been accepted mostly as the key step in production of oxy-radicals mediated myocardial damage. Allopurinol, a xanthine oxidase inhibitor and inhibitor of uric acid formation has been selected as one of the antioxidants in this study. Allopurinol showed decreased mortality in the test animals. It has also reduced the ST elevation in post- reperfusion stage. It has also attenuated the infarct size significantly (p<0.05) owing to its capability to prevent excess formation of oxyradicals. It has also been substantiated that not acutely but chronically administered xanthine oxidase inhibitors may have its more profound anti-oxidant effect.
Authors and Affiliations
Dr. Ambrish Kumar Gupta
Keywords
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