Longitudinal effects of in utero methadone exposure on development using revised norms on the Bayley Scales of Infant Development (BSID)
Journal Title: International Journal of Research in Pharmacology & Pharmacotherapeutics (IJRPP) - Year 2017, Vol 6, Issue 2
Abstract
Much of the scientific justification for using methadone to treat women with heroin use disorders relies on one heavily cited early review of five studies. The review concluded there were no long-term developmental effects directly associated with prenatal methadone exposure because scores for exposed infants on the Psychomotor Development Index (PDI) of the Bayley Scales of Infant Development fell “well within the normal range of development.” However, three of the studies reviewed reported significant differences between exposed and control infants on the PDI. The other two did not report scores on the PDI. The PDI is a subscale of the Bayley Scales of Infant Development, which was released with a much more extensive normative sample in 1993. Extrapolating PDI scores from the earlier version to the better 1993 version reveals that methadone-exposed infants were not well within the normal range of development. Given the increasingly higher doses of methadone used to treat pregnant opioid-dependent women, we are concerned about the potential for greater adverse effects in the present era. Beginning with the seminal review, this paper examines subsequent studies for longitudinal outcomes for prenatally exposed infants. We hypothesize that revised BSID-II PDI scores will reveal motor effects for infants born to women with heroin use disorders treated with methadone.
Authors and Affiliations
Sherry Dingman
Keywords
Related Articles
- EP ID EP412948
- DOI -
- Views 99
- Downloads 0
In vitro studies on phytochemical analysis and antioxidant activity of Manilkara zapota
Sapota is one of the prominent fruits and belongs to family sapotaceae. India is the largest producer of sapota. In this present study, phytochemicals were analysed and antioxidant activity was determined for sapota frui...
The scenario of COPD in Dhaka city Bangladesh: Extensive analysis of the prevalence, manifestations and standards of diagnosis and treatment
Chronic Obstructive Pulmonary Disease (COPD) is a slowly progressive disease which is characterized by airflow obstruction mainly caused by bronchitis. Our study focused on the scenario of COPD in Dhaka, Bangladesh. A cr...
Assessment of factors influencing self reported drug adherence to anti-epileptic drugs at a tertiary care hospital
Background Epilepsy is one of the most common neurological disorders worldwide which requires incorporation of complex therapeutic regimens in daily routines. Success of the antiepileptic drugs (AEDs) regimen depends on...
Ebola virus disease - A comprehensive review
Ebola virus disease (EVD) is caused by infection with Ebola virus. Ebola virus disease first appeared in 1976 in 2 simultaneous outbreaks, one in Nzara, Sudan, and the other in Yambuku, Democratic Republic of Congo. The...
Medication Adherence Pattern Of Hypertensive Patients In Rural Area
AIM & OBJECTIVES The study investigated the level of drug adherence among hypertensive patients at a tertiary care hospital in Erode, Tamil Nadu. Specific objectives included measurement of blood pressure (BP) control a...