Plasma lipid profile patterns in oral leukoplakia and oral squamous cell carcinoma
Journal Title: International Journal of Research in Pharmacology & Pharmacotherapeutics (IJRPP) - Year 2017, Vol 6, Issue 3
Abstract
Background Changes in the lipid profile has been reported to be associated with oral cancer and also in cases of oral premalignant lesions and conditions. This study was done to assess the relationship between plasma lipid profile and oral squamous cell carcinoma (OSCC) and oral leukoplakia (OL). OL is a potentially malignant lesion which could transform into malignancy hence this study evaluates the correlation of cholesterol levels and leukoplakia and also the tobacco abusers. Aims to assess the serum lipid levels in OL and OSCC and to look for any relation between incidence of OL and OSCC and lipid profile levels Settings and design This study included a total of 126 subjects of which 30 had OL and 30 had OSCC and 66 were age and sex matched controls. Materials and methods Analysis of total cholesterol (TC), low density lipoprotein (LDL), high density lipoprotein (HDL), very low density lipoprotein (VLDL), triglycerides (TGL) levels were done using the standard reagents from erba diagnostics, Daman. Statistical analysis used SPSS package 14th version and ANOVA was used for multiple group comparison followed by students T test for pair wise comparison. Results Plasma levels of HDL, VLDL, TGL and ratio of HDL and LDL was significantly reduced in patients with OSCC and OL. Plasma TC and LDL was significantly reduced in patients with speckled leukoplakia when compared with the rest of the types. Conclusions There was a inverse relationship between lipid profile and OSCC and OL.
Authors and Affiliations
Dr. Shantala R Naik
Keywords
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