A Study of Serum Calcium, Magnesium and Phosphorous Level in Hypothyroidism Patients
Journal Title: International Journal of Medical and Health Sciences - Year 2014, Vol 3, Issue 4
Abstract
Introduction: Hypothyroidism is one of the most common forms of thyroid dysfunction resulting from the deficiency of thyroid hormones. Mineral metabolism is frequently disturbed in thyroid dysfunctions. Previous studies done on serum calcium, magnesium and phosphorous levels in thyroid disorders have conflicting results. The present study has been undertaken to study the serum total calcium, total magnesium and phosphorous levels in patients with hypothyroidism. Materials and Methods: A hospital based cross sectional study consists of 100 cases of hypothyroidism and 100 normal healthy controls meeting the selection criteria. Serum calcium total, magnesium total and phosphorous level along with thyroid profile was measured. Results: Statistically significant decrease in serum total calcium and total magnesium level as well as increase in serum phosphorous level is found in cases compared to control (p<0.001). A statistically significant negative correlation between serum TSH with calcium total and magnesium total levels was noticed (p<0.001). Also statistically significant positive correlation between serum TSH and phosphorous levels was observed. Conclusions: Serum calcium, magnesium & phosphorous levels are significantly altered in patients having hypothyroidism. Thyroid diseases have wide spread systemic manifestations including their effects on bone and mineral metabolism. Also thyroid hormone affects the glomerular filtration rate, renal blood flow, tubular reabsorption and excretion of minerals which have direct effect on Calcium, Magnesium and phosphorous level. Thus monitoring of these minerals in hypothyroid patient will be of great benefit in improving clinical manifestation and can be treated appropriately.
Authors and Affiliations
Mukesh G Gohel, Aashka M Shah, Akash M. Shah, Jemil S Makadia
Keywords
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